DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population.
Adolescent
Adult
Aged
Aged, 80 and over
Chromosome Aberrations
Computer Simulation
Czech Republic
DNA Mismatch Repair
/ genetics
DNA Repair
/ genetics
DNA Repair Enzymes
/ genetics
DNA-Binding Proteins
/ genetics
Female
Genome-Wide Association Study
Healthy Volunteers
Humans
Male
Middle Aged
Non-Smokers
Poly(ADP-ribose) Polymerases
/ genetics
Polymorphism, Single Nucleotide
RecQ Helicases
/ genetics
Replication Protein A
/ genetics
Slovakia
Werner Syndrome Helicase
/ genetics
White People
/ genetics
Young Adult
Association study
Chromosomal aberrations
DNA repair
Double-strand breaks
Journal
DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
13
10
2020
revised:
21
02
2021
accepted:
24
02
2021
pubmed:
7
3
2021
medline:
13
8
2021
entrez:
6
3
2021
Statut:
ppublish
Résumé
Nonspecific structural chromosomal aberrations (CAs) can be found at around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. The frequency of CAs has been measured in occupational monitoring and an increased frequency of CAs has also been associated with cancer risk. Alterations in DNA damage repair and telomere maintenance are thought to contribute to the formation of CAs, which include chromosome type of aberrations and chromatid type of aberrations. In the present study, we used the result of our published genome-wide association studies to extract data on 153 DNA repair genes from 866 nonsmoking persons who had no known occupational exposure to genotoxic substances. Considering an arbitrary cut-off level of P< 5 × 10
Identifiants
pubmed: 33676360
pii: S1568-7864(21)00035-5
doi: 10.1016/j.dnarep.2021.103079
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
NHEJ1 protein, human
0
RPA3 protein, human
0
Replication Protein A
0
PARP2 protein, human
EC 2.4.2.30
Poly(ADP-ribose) Polymerases
EC 2.4.2.30
RPA2 protein, human
EC 2.7.7.7
Bloom syndrome protein
EC 3.6.1.-
RecQ Helicases
EC 3.6.4.12
WRN protein, human
EC 3.6.4.12
Werner Syndrome Helicase
EC 3.6.4.12
DNA Repair Enzymes
EC 6.5.1.-
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103079Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.