Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production.
Animals
Computational Biology
/ methods
Energy Metabolism
Gene Expression Profiling
Gene Expression Regulation
Hepatocytes
/ metabolism
Homeostasis
Hypoxia
/ genetics
Indoleamine-Pyrrole 2,3,-Dioxygenase
/ genetics
Liver
/ metabolism
Mice
Models, Biological
Oxygen
/ metabolism
Tryptamines
/ metabolism
Tryptophan
/ metabolism
AHR activity
TDO2
hallucination
hypoxia
liver
regulation
tryptamine
tryptophan
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
01
08
2020
accepted:
04
01
2021
entrez:
8
3
2021
pubmed:
9
3
2021
medline:
2
7
2021
Statut:
epublish
Résumé
The liver is the central hub for processing and maintaining homeostatic levels of dietary nutrients especially essential amino acids such as tryptophan (Trp). Trp is required not only to sustain protein synthesis but also as a precursor for the production of NAD, neurotransmitters and immunosuppressive metabolites. In light of these roles of Trp and its metabolic products, maintaining homeostatic levels of Trp is essential for health and well-being. The liver regulates global Trp supply by the immunosuppressive enzyme tryptophan-2,3-dioxygenase (TDO2), which degrades Trp down the kynurenine pathway (KP). In the current study, we show that isolated primary hepatocytes when exposed to hypoxic environments, extensively rewire their Trp metabolism by reducing constitutive
Identifiants
pubmed: 33679737
doi: 10.3389/fimmu.2021.590532
pmc: PMC7933006
doi:
Substances chimiques
Indoleamine-Pyrrole 2,3,-Dioxygenase
0
Tryptamines
0
tryptamine
422ZU9N5TV
Tryptophan
8DUH1N11BX
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
590532Informations de copyright
Copyright © 2021 Mohapatra, Sadik, Sharma, Poschet, Gegner, Lanz, Lucarelli, Klingmüller, Platten, Heiland and Opitz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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