Visualizing Cholesterol in the Brain by On-Tissue Derivatization and Quantitative Mass Spectrometry Imaging.
Journal
Analytical chemistry
ISSN: 1520-6882
Titre abrégé: Anal Chem
Pays: United States
ID NLM: 0370536
Informations de publication
Date de publication:
23 03 2021
23 03 2021
Historique:
pubmed:
10
3
2021
medline:
22
6
2021
entrez:
9
3
2021
Statut:
ppublish
Résumé
Despite being a critical molecule in the brain, mass spectrometry imaging (MSI) of cholesterol has been under-reported compared to other lipids due to the difficulty in ionizing the sterol molecule. In the present work, we have employed an on-tissue enzyme-assisted derivatization strategy to improve detection of cholesterol in brain tissue sections. We report distribution and levels of cholesterol across specific structures of the mouse brain, in a model of Niemann-Pick type C1 disease, and during brain development. MSI revealed that in the adult mouse, cholesterol is the highest in the pons and medulla and how its distribution changes during development. Cholesterol was significantly reduced in the corpus callosum and other brain regions in the
Identifiants
pubmed: 33687199
doi: 10.1021/acs.analchem.0c05399
pmc: PMC7992047
doi:
Substances chimiques
Sterols
0
Cholesterol
97C5T2UQ7J
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4932-4943Subventions
Organisme : NIMH NIH HHS
ID : R01 MH110636
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N015932/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/L001942/1
Pays : United Kingdom
Références
J Lipid Res. 2011 Jan;52(1):6-34
pubmed: 20929975
J Biol Chem. 2017 Mar 24;292(12):4913-4924
pubmed: 28190002
Neuroscience. 2002;109(3):437-50
pubmed: 11823057
J Lipid Res. 2010 Sep;51(9):2489-503
pubmed: 20466796
Anal Chem. 2015 Jan 6;87(1):64-82
pubmed: 25490190
J Steroid Biochem Mol Biol. 2019 Sep;192:105309
pubmed: 30779932
Neuroscience. 2010 Oct 27;170(3):858-64
pubmed: 20670678
Anal Chem. 2015 Feb 3;87(3):1749-56
pubmed: 25548943
Anal Chem. 2013 Mar 19;85(6):3318-24
pubmed: 23425078
Nature. 2007 Jan 11;445(7124):168-76
pubmed: 17151600
Neuroradiology. 1994;36(1):20-2
pubmed: 8107989
Anal Chem. 2013 Dec 3;85(23):11576-84
pubmed: 24134553
Lancet. 2014 Jun 28;383(9936):2213-21
pubmed: 24655729
Nat Methods. 2019 Sep;16(9):925-931
pubmed: 31451764
Biol Chem. 2009 Apr;390(4):287-93
pubmed: 19166320
J Am Soc Mass Spectrom. 2017 Aug;28(8):1716-1728
pubmed: 28432654
Eur J Pediatr. 1981 Jul;136(3):263-74
pubmed: 7262098
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2377-82
pubmed: 19171898
Anal Chem. 2016 Dec 20;88(24):12051-12059
pubmed: 28193015
Brain Res. 1984 Jul;317(1):59-67
pubmed: 6467032
J Inherit Metab Dis. 2015 Jan;38(1):187-99
pubmed: 25425283
Anal Chem. 2020 Jul 7;92(13):8697-8703
pubmed: 32449347
Sci Rep. 2017 Dec 4;7(1):16878
pubmed: 29203879
Rapid Commun Mass Spectrom. 2008 May;22(10):1503-9
pubmed: 18421763
Anal Chem. 1997 Dec 1;69(23):4751-60
pubmed: 9406525
Methods Enzymol. 2007;432:145-70
pubmed: 17954216
Science. 2000 Dec 1;290(5497):1721-6
pubmed: 11099405
J Lipid Res. 2004 Aug;45(8):1375-97
pubmed: 15254070
Biochim Biophys Acta. 2015 Aug;1851(8):1083-94
pubmed: 25724171
Dev Disabil Res Rev. 2013;17(3):197-210
pubmed: 23798009
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5749-5760
pubmed: 32132201
J Lipid Res. 2004 Jan;45(1):186-93
pubmed: 14523054
Anal Chem. 2004 Aug 1;76(15):4271-8
pubmed: 15283560
Am J Pathol. 1982 Aug;108(2):140-9
pubmed: 6765731
Biochem Soc Trans. 2019 Apr 30;47(2):517-526
pubmed: 30936243
Anal Chem. 2019 Aug 20;91(16):10840-10848
pubmed: 31355633
Chem Rev. 2011 Oct 12;111(10):6491-512
pubmed: 21942646
Brain Res Dev Brain Res. 2003 Dec 19;146(1-2):87-98
pubmed: 14643015
Acta Neuropathol. 1993;85(2):175-84
pubmed: 8382896
Clin Chem. 2015 Feb;61(2):400-11
pubmed: 25512642
J Neuropathol Exp Neurol. 1953 Oct;12(4):400-3
pubmed: 13097193
Neuroimage. 2009 Jun;46(2):382-93
pubmed: 19385012
J Lipid Res. 2018 Dec;59(12):2446-2455
pubmed: 30266834