Biologically active phthalocyanine metal complexes: Preparation, evaluation of α-glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies.
Acetylcholinesterase
/ chemistry
Cholinesterase Inhibitors
/ chemical synthesis
Coordination Complexes
/ chemical synthesis
Drug Evaluation
GPI-Linked Proteins
/ antagonists & inhibitors
Glycoside Hydrolase Inhibitors
/ chemical synthesis
Humans
Indoles
/ chemical synthesis
Isoindoles
Molecular Docking Simulation
alpha-Glucosidases
/ chemistry
cholinesterases
enzyme inhibition
molecular docking
phthalocyanine
α-glycosidase
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
revised:
01
02
2021
received:
14
09
2020
accepted:
02
03
2021
pubmed:
12
3
2021
medline:
28
7
2021
entrez:
11
3
2021
Statut:
ppublish
Résumé
In this study, preparation, as well as investigation of α-glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan-2-ylmethoxy-substituted compounds 1-7, are reported. Peripherally, tetra-substituted copper and manganese phthalocyanines (5 and 6) were synthesized for the first time. The substitution of furan-2-ylmethoxy groups provides remarkable solubility to the complex and redshift of the phthalocyanines Q-band. Besides, the inhibitory effects of these compounds on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glycosidase (α-Gly) enzymes have been investigated. The AChE was inhibited by these compounds (1-7) in low micromolar levels, and K
Substances chimiques
Cholinesterase Inhibitors
0
Coordination Complexes
0
GPI-Linked Proteins
0
Glycoside Hydrolase Inhibitors
0
Indoles
0
Isoindoles
0
ACHE protein, human
EC 3.1.1.7
Acetylcholinesterase
EC 3.1.1.7
alpha-Glucosidases
EC 3.2.1.20
phthalocyanine
V5PUF4VLGY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-9Informations de copyright
© 2021 Wiley Periodicals LLC.
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