Therapeutic Implications of Targeting Heat Shock Protein 70 by Immunization or Antibodies in Experimental Skin Inflammation.
Animals
Antibodies
/ immunology
Biomarkers
Biopsy
Cytokines
/ metabolism
Dermatitis
/ diagnosis
Disease Models, Animal
Disease Susceptibility
/ immunology
Female
HSP70 Heat-Shock Proteins
/ antagonists & inhibitors
Immunization
Immunophenotyping
Inflammation Mediators
/ metabolism
Keratinocytes
/ drug effects
Mice
Recombinant Proteins
T-Lymphocytes, Regulatory
/ drug effects
Th17 Cells
/ drug effects
Hsp70
Th17
Treg
heat shock proteins
immunization
psoriasis
regulatory T cells
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
10
2020
accepted:
07
01
2021
entrez:
12
3
2021
pubmed:
13
3
2021
medline:
6
7
2021
Statut:
epublish
Résumé
Heat shock proteins (Hsp) are constitutive and stress-induced molecules which have been reported to impact innate and adaptive immune responses. Here, we evaluated the role of Hsp70 as a treatment target in the imiquimod-induced, psoriasis-like skin inflammation mouse model and related
Identifiants
pubmed: 33708208
doi: 10.3389/fimmu.2021.614320
pmc: PMC7940535
doi:
Substances chimiques
Antibodies
0
Biomarkers
0
Cytokines
0
HSP70 Heat-Shock Proteins
0
Inflammation Mediators
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
614320Informations de copyright
Copyright © 2021 Tukaj, Mantej, Sobala, Potrykus, Tukaj, Zillikens, Ludwig, Bieber and Kasperkiewicz.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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