The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation.

Animals Biomarkers Cell Differentiation / genetics Child, Preschool Chromatin Assembly and Disassembly Enhancer Elements, Genetic Epigenesis, Genetic Gene Expression Regulation HLA Antigens / genetics Humans Immunophenotyping Infant Killer Cells, Natural / cytology Mice Mice, Knockout Receptors, KIR / genetics Repressor Proteins / genetics T-Lymphocyte Subsets / immunology Transcriptome Tumor Suppressor Proteins / genetics

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
12 03 2021
Historique:
received: 05 06 2020
accepted: 11 02 2021
entrez: 13 3 2021
pubmed: 14 3 2021
medline: 19 2 2022
Statut: ppublish

Résumé

Epigenetic landscapes can provide insight into regulation of gene expression and cellular diversity. Here, we examined the transcriptional and epigenetic profiles of seven human blood natural killer (NK) cell populations, including adaptive NK cells. The

Identifiants

DOI: 10.1126/sciimmunol.abc9801 PMID: 33712472 PMC: PMC8274449
pubmed: 33712472
pii: 6/57/eabc9801
doi: 10.1126/sciimmunol.abc9801
pmc: PMC8274449
mid: NIHMS1713470
pii:
doi:

Substances chimiques

BCL11B protein, human 0
Bcl11b protein, mouse 0
Biomarkers 0
HLA Antigens 0
Receptors, KIR 0
Repressor Proteins 0
Tumor Suppressor Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R00 HL123638
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA065493
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK074367
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI067846
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL123638
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Tim D Holmes (TD)

Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway. tim.holmes@uib.no yenan.bryceson@ki.se.
Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
ORCID: 0000-0002-9348-3982

Ram Vinay Pandey (RV)

Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
ORCID: 0000-0001-7420-4346

Eric Y Helm (EY)

Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
ORCID: 0000-0001-6128-5204

Heinrich Schlums (H)

Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
ORCID: 0000-0002-2895-7766

Hongya Han (H)

Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.

Tessa M Campbell (TM)

Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
ORCID: 0000-0002-7737-2123

Theodore T Drashansky (TT)

Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
ORCID: 0000-0001-6215-1232

Samuel Chiang (S)

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Cheng-Ying Wu (CY)

Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.
ORCID: 0000-0001-7765-9389

Christine Tao (C)

Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

Moneef Shoukier (M)

Prenatal Medicine Munich, Munich, Germany.
ORCID: 0000-0002-9237-4696

Eva Tolosa (E)

Department of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-5247-8378

Sandra Von Hardenberg (S)

Department of Human Genetics, Hannover Medical University, Hannover, Germany.
ORCID: 0000-0002-3680-7450

Miao Sun (M)

Division of Human Genetics, Cincinnati Children's Hospital Medical Center College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA.
Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45221, USA.
ORCID: 0000-0002-3074-8330

Christian Klemann (C)

Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.
ORCID: 0000-0002-5639-8690

Rebecca A Marsh (RA)

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45221, USA.

Colleen M Lau (CM)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0001-7538-094X

Yin Lin (Y)

Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75246, USA.

Joseph C Sun (JC)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
ORCID: 0000-0001-8062-9033

Robert Månsson (R)

Centre for Hematology and Regenerative Medicine, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
ORCID: 0000-0003-0738-0328

Frank Cichocki (F)

Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA.
ORCID: 0000-0003-3043-0653

Dorina Avram (D)

Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
ORCID: 0000-0003-1254-1122

Yenan T Bryceson (YT)

Broegelmann Research Laboratory, Department of Clinical Sciences, University of Bergen, N-5021 Bergen, Norway. tim.holmes@uib.no yenan.bryceson@ki.se.
Centre for Hematology and Regenerative Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
ORCID: 0000-0002-7783-9934

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Cellules tueuses naturelles › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de cellules tueuses naturelles › Récepteurs KIR › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › The transcription factor Bcl11b promotes both...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › The transcription factor Bcl11b promotes both...