Hypoglycemia during the Concomitant Use of Repaglinide and Clopidogrel in an Elderly Patient with Type 2 Diabetes and Severe Renal Insufficiency.
clopidogrel
cytochrome P450 2C8
diabetes
hypoglycemia
renal insufficiency
repaglinide
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
15
4
2021
Statut:
ppublish
Résumé
Hypoglycemia should be avoided when treating patients with diabetes. Repaglinide is an insulin secretagogue with a low hypoglycemic risk because of its rapid- and short-acting effects. However, its blood concentration has been reported to increase in combination with clopidogrel, an antiplatelet drug, and in patients with severe renal insufficiency. We herein report an elderly patient with type 2 diabetes mellitus and severe renal insufficiency who received repaglinide and hypoglycemia three days after starting clopidogrel. The concomitant use of repaglinide and clopidogrel can lead to hypoglycemia, especially in patients with severe renal insufficiency.
Identifiants
pubmed: 33716254
doi: 10.2169/internalmedicine.5578-20
pmc: PMC8024957
doi:
Substances chimiques
Blood Glucose
0
Carbamates
0
Hypoglycemic Agents
0
Piperidines
0
repaglinide
668Z8C33LU
Clopidogrel
A74586SNO7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
905-910Références
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