Do Molecular Profiles of Primary
Adenocarcinoma, Follicular
/ genetics
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
/ genetics
Cross-Sectional Studies
Female
Gene Expression Profiling
High-Throughput Nucleotide Sequencing
Humans
Iodine Radioisotopes
/ therapeutic use
Male
Middle Aged
Thyroid Cancer, Papillary
/ genetics
Thyroid Neoplasms
/ genetics
differentiated thyroid cancer
metastases
molecular profile
next generation sequencing
radioiodine refractory
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
10
2020
accepted:
18
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
17
12
2021
Statut:
epublish
Résumé
Management of metastatic radioiodine refractory differentiated thyroid cancer (DTC) can be a therapeutic challenge. Generally, little is known about the paired molecular profile of the primary tumor and the metastases and whether they harbor the same genetic abnormalities. The present study compared the molecular profile of paired tumor specimens (primary tumor/metastatic sites) from patients with radioiodine refractory DTC in order to gain insight into a possible basis for resistance to radioiodine. Twelve patients with radioiodine refractory metastases were studied; median age at diagnosis of 61 years (range, 25-82). Nine patients had papillary TC (PTC), one had follicular TC (FTC), and two had Hürthle cell TC (HTC). Distant metastases were present in the lungs (n = 10), bones (n = 4), and liver (n = 1). The molecular profiling of paired tumors was performed with a panel of 592 genes for Next Generation Sequencing, RNA-sequencing, and immunohistochemistry. Digital microfluidic PCR was used to investigate
Identifiants
pubmed: 33716974
doi: 10.3389/fendo.2021.623182
pmc: PMC7949910
doi:
Substances chimiques
Biomarkers, Tumor
0
Iodine Radioisotopes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
623182Informations de copyright
Copyright © 2021 Gomes-Lima, Shobab, Wu, Ylli, Bikas, McCoy, Feldman, Lee, Rao, Jensen, Vasko, Castro, Jonklaas, Wartofsky and Burman.
Déclaration de conflit d'intérêts
RF is employed by Caris Life Sciences. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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