Apoptotic Donor Cells in Transplantation.
Animals
Antigen-Presenting Cells
/ immunology
Apoptosis
Cell- and Tissue-Based Therapy
/ methods
Chimerism
Graft Rejection
/ immunology
Graft vs Host Disease
/ immunology
Humans
Immunosuppressive Agents
/ therapeutic use
Organ Transplantation
Tissue Donors
Transplantation Immunology
Transplantation Tolerance
Ureohydrolases
/ immunology
EDCI-SP
apoptosis
cell-based therapies
tolerance
transplantation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
11
2020
accepted:
18
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
4
8
2021
Statut:
epublish
Résumé
Despite significant advances in prevention and treatment of transplant rejection with immunosuppressive medications, we continue to face challenges of long-term graft survival, detrimental medication side effects to both the recipient and transplanted organ together with risks for opportunistic infections. Transplantation tolerance has so far only been achieved through hematopoietic chimerism, which carries with it a serious and life-threatening risk of graft versus host disease, along with variability in persistence of chimerism and uncertainty of sustained tolerance. More recently, numerous
Identifiants
pubmed: 33717145
doi: 10.3389/fimmu.2021.626840
pmc: PMC7947657
doi:
Substances chimiques
Immunosuppressive Agents
0
Ureohydrolases
EC 3.5.3.-
allantoicase
EC 3.5.3.4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
626840Informations de copyright
Copyright © 2021 Husain and Luo.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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