HLA-Restriction of Human Treg Cells Is Not Required for Therapeutic Efficacy of Low-Dose IL-2 in Humanized Mice.
IBD
IL-2
Tregs
colitis
humanized
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
11
2020
accepted:
15
01
2021
entrez:
15
3
2021
pubmed:
16
3
2021
medline:
21
9
2021
Statut:
epublish
Résumé
Regulatory T (T
Identifiants
pubmed: 33717161
doi: 10.3389/fimmu.2021.630204
pmc: PMC7945590
doi:
Substances chimiques
HLA Antigens
0
Interleukin-2
0
Trinitrobenzenesulfonic Acid
8T3HQG2ZC4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
630204Subventions
Organisme : CSRD VA
ID : I01 CX002171
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01 DK106311
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK058404
Pays : United States
Informations de copyright
Copyright © 2021 Tyagi, Jacobse, Li, Allaman, Otipoby, Sampson, Wilson and Goettel.
Déclaration de conflit d'intérêts
ES and KO are employed by Pandion Therapeutics. The authors declare that financial support for some of the humanized murine studies was provided by Pandion Therapeutics. The funder was, in part, involved in study design and procurement of mice. The data collection and analysis was not a part of the funding provided. The authors shared the results of the study with Pandion and shared the manuscript draft for critiques prior to submission. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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