Sphingolipid long-chain base hydroxylation influences plant growth and callose deposition in Physcomitrium patens.
Physcomitrium patens
LCB hydroxylation
callose
long-chain base (LCB) C-4 hydroxylase
microdomain
nonvascular plants
plant development
sphingolipid metabolism
Journal
The New phytologist
ISSN: 1469-8137
Titre abrégé: New Phytol
Pays: England
ID NLM: 9882884
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
30
10
2020
accepted:
08
03
2021
pubmed:
16
3
2021
medline:
11
6
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
Sphingolipids are enriched in microdomains in the plant plasma membrane (PM). Hydroxyl groups in the characteristic long-chain base (LCB) moiety might be essential for the interaction between sphingolipids and sterols during microdomain formation. Investigating LCB hydroxylase mutants in Physcomitrium patens might therefore reveal the role of certain plant sphingolipids in the formation of PM subdomains. Physcomitrium patens mutants for the LCB C-4 hydroxylase S4H were generated by homologous recombination. Plants were characterised by analysing their sphingolipid and steryl glycoside (SG) profiles and by investigating different gametophyte stages. s4h mutants lost the hydroxyl group at the C-4 position of their LCB moiety. Loss of this hydroxyl group caused global changes in the moss sphingolipidome and in SG composition. Changes in membrane lipid composition may trigger growth defects by interfering with the localisation of membrane-associated proteins that are crucial for growth processes such as signalling receptors or callose-modifying enzymes. Loss of LCB-C4 hydroxylation substantially changes the P. patens sphingolipidome and reveals a key role for S4H during development of nonvascular plants. Physcomitrium patens is a valuable model for studying the diversification of plant sphingolipids. The simple anatomy of P. patens facilitates visualisation of physiological processes in biological membranes.
Substances chimiques
Glucans
0
Sphingolipids
0
callose
9064-51-1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-314Informations de copyright
© 2021 The Authors New Phytologist © 2021 New Phytologist Foundation.
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