Three SNPs within exons of INHA and ACVR2B genes are significantly associated with litter size in Dazu black goats.
ACVR2B
INHA
Dazu black goat
litter size
single-nucleotide polymorphism
Journal
Reproduction in domestic animals = Zuchthygiene
ISSN: 1439-0531
Titre abrégé: Reprod Domest Anim
Pays: Germany
ID NLM: 9015668
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
30
07
2020
accepted:
12
03
2021
pubmed:
16
3
2021
medline:
21
10
2021
entrez:
15
3
2021
Statut:
ppublish
Résumé
The aim of this study was to analyse the association between single-nucleotide polymorphisms within INHA and ACVR2B and litter size in Dazu black goats. In total, twenty-two SNPs were genotyped in 190 individuals by SNaPshot and resequencing. The results showed that three SNPs (SNP_1, SNP_12 and SNP_13 in this study) were detected to have significant additive genetic effect on the recorded goat litter size (p < .05). The SNP_1 (NC_030809.1), a non-synonymous substitution of G for T at chr2-g. 28314990 in the exon 2 of INHA gene (NM_001285606.1), resulted in homozygote 2 (HOM2) contributed 0.25 and heterozygote (HET) contributed 0.12 larger litter than homozygote 1 (HOM1). Meanwhile, SNP_12 (Chr22-g. 11721225 A > T) and SNP_13 (Chr22-g. 11721227 A > C) (NC_030829.1) simultaneously mutated at the first and third position of a triplet AAA (lysine, K) in the exon 4 of ACVR2B gene (XM_018066623.1) had estimated genetic effects of HOM1 (0.00) and HOM2 (0.03) larger than HET (-0.12). In conclusion, one SNPs (chr2-g. 28314990 T > G) within the exon 2 of INHA and two SNPs (Chr22-g. 11721225 A > T and Chr22-g. 11721227 A > C) in the exon 4 of ACVR2B gene were highly recommended as candidate markers of litter size in Dazu black goats. A large-scale association study to assess the impact of these variants on litter size is still necessary.
Substances chimiques
Inhibins
57285-09-3
Activin Receptors, Type II
EC 2.7.11.30
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
936-941Subventions
Organisme : Fundamental Research Funds for the Central Universities
ID : XDJK2019B049
Organisme : Venture & Innovation Support Program for Chongqing Overseas Returnees
ID : cx2019132
Organisme : National Natural Science Foundation of China
ID : 31301944
Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
Cui, Z., Liu, L., Zhao, X., Ran, J., Wang, Y., Yin, H., Li, D., & Zhu, Q. (2019). Analysis of expression and single nucleotide polymorphisms of INHA Gene associated with reproductive traits in chickens. BioMed Research International, 2019, 8572837. https://doi.org/10.1155/2019/8572837
Fatet, A., Pellicer-Rubio, M. T., & Leboeuf, B. (2011). Reproductive cycle of goats. Animal Reproduction Science, 124(3-4), 211-219. https://doi.org/10.1016/j.anireprosci.2010.08.029
Guang-Xin, E, Zhou, D.-K., Yang, B.-G., Duan, X.-H., Na, R.-S., Han, Y.-G., & Zeng, Y. (2020). Association analysis of sixty-seven single nucleotide polymorphisms with litter size in Dazu black goats. Animal Genetics, 51(1), 151-152. https://doi.org/10.1111/age.12879
Li, W., Chen, S., Li, H., Liu, Z., Zhao, Y., Chen, L., Zhou, X., & Li, C. (2016). A new insertion/deletion fragment polymorphism of inhibin-alpha gene associated with follicular cysts in Large White sows. Journal of Veterinary Medical Science, 78(3), 473-476. https://doi.org/10.1292/jvms.14-0489
Li, W., Sun, L., Chen, S., Chen, L., Liu, Z., Hou, X., Chen, C., Han, Y., Wang, C., Li, C., & Zhou, X. (2015). Association of inhibin-alpha gene polymorphisms with follicular cysts in large white sows. Theriogenology, 84(6), 839-845. https://doi.org/10.1016/j.theriogenology.2014.06.028
Olsen, O. E., Wader, K. F., Hella, H., Mylin, A. K., Turesson, I., Nesthus, I., Waage, A., Sundan, A., & Holien, T. (2015). Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B. Cell Communication and Signaling, 13, 27. https://doi.org/10.1186/s12964-015-0104-z
Pyun, J. A., Kim, S., & Kwack, K. (2015). Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. Menopause, 22(2), 212-216. https://doi.org/10.1097/GME.0000000000000285
Rafaqat, W., Kayani, M. R., Fatima, T., Shaharyar, S., Khan, S., Ashraf, M., Afzal, U., & Rehman, R. (2020). Association of polymorphism c.-124G>A and c.-16 C>T in the promoter region of human INHA gene with altered sperm parameters; a pilot study. International Journal of Clinical Practice, 74(10), e13595. https://doi.org/10.1111/ijcp.13595
Rah, H., Jeon, Y. J., Ko, J. J., Kim, J. H., Kim, Y. R., Cha, S. H., Choi, Y., Lee, W. S., & Kim, N. K. (2014). Association of inhibin alpha gene promoter polymorphisms with risk of idiopathic primary ovarian insufficiency in Korean women. Maturitas, 77(2), 163-167. https://doi.org/10.1016/j.maturitas.2013.10.015
Sang, L., Du, Q. Z., Yang, W. C., Tang, K. Q., Yu, J. N., Hua, G. H., Zhang, X. X., & Yang, L. G. (2011). Polymorphisms in follicle stimulation hormone receptor, inhibin alpha, inhibin bata A, and prolactin genes, and their association with sperm quality in Chinese Holstein bulls. Anim Reprod Sci, 126(3-4), 151-156. https://doi.org/10.1016/j.anireprosci.2011.04.023
Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brule, E., Boehm, U., Lee, S. J., & Bernard, D. J. (2020). Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B. Endocrinology, 161(7), bqaa056. https://doi.org/10.1210/endocr/bqaa056
Seachrist, D. D., & Keri, R. A. (2019). The activin social network: Activin, inhibin, and follistatin in breast development and cancer. Endocrinology, 160(5), 1097-1110. https://doi.org/10.1210/en.2019-00015
Tang, K. Q., Li, S. J., Yang, W. C., Yu, J. N., Han, L., Li, X., & Yang, L. G. (2011). An MspI polymorphism in the inhibin alpha gene and its associations with superovulation traits in Chinese Holstein cows. Molecular Biology Reports, 38(1), 17-21. https://doi.org/10.1007/s11033-010-0072-8
Woad, K. J., Pearson, S. M., Harris, S. E., Gersak, K., & Shelling, A. N. (2009). Investigating the association between inhibin alpha gene promoter polymorphisms and premature ovarian failure. Fertility and Sterility, 91(1), 62-66. https://doi.org/10.1016/j.fertnstert.2007.11.012
Yang, M. B., Yang, L., Wang, X. Z., & Zhang, J. H. (2009). Follicle waves of Dazu black goats. Heilongjiang Animal Science and Veterinary Medicine, 21, 34-36.(in Chinese).
Yang, M. B., Zheng, S. Y., Yang, L., Wang, X. Z., & Zhang, J. H. (2010). Differences of follicle development between right and left ovaries in Dazu black goats. Heilongjiang Animal Science and Veterinary Medicine, 5, 60-61.(in Chinese).
Yang, W. C., Li, S. J., Chen, L., & Yang, L. G. (2014). Polymorphism of the inhibin betaA gene and its relationship with superovulation traits in Chinese Holstein cows. Genetics and Molecular Research, 13(1), 269-275. https://doi.org/10.4238/2014.January.17.11