The role of inflammatory mediators in epilepsy: Focus on developmental and epileptic encephalopathies and therapeutic implications.

Animals Chemokines Cytokines Epilepsy / drug therapy Immunomodulating Agents Inflammation Mediators Neuroinflammatory Diseases
Chemokine Cytokine Epilepsy Neuroinflammation Steroid West syndrome

Journal

Epilepsy research
ISSN: 1872-6844
Titre abrégé: Epilepsy Res
Pays: Netherlands
ID NLM: 8703089

Informations de publication

Date de publication:
05 2021
Historique:
received: 14 12 2020
revised: 28 01 2021
accepted: 16 02 2021
pubmed: 16 3 2021
medline: 26 2 2022
entrez: 15 3 2021
Statut: ppublish

Résumé

In recent years, there has been an increasing interest in the potential involvement of neuroinflammation in the pathogenesis of epilepsy. Specifically, the role of innate immunity (that includes cytokines and chemokines) has been extensively investigated either in animal models of epilepsy and in clinical settings. Developmental and epileptic encephalopathies (DEE) are a heterogeneous group of epileptic disorders, in which uncontrolled epileptic activity results in cognitive, motor and behavioral impairment. By definition, epilepsy in DEE is poorly controlled by common antiepileptic drugs but may respond to alternative treatments, including steroids and immunomodulatory drugs. In this review, we will focus on how cytokines and chemokines play a role in the pathogenesis of DEE and why expanding our knowledge about the role of neuroinflammation in DEE may be crucial to develop new and effective targeted therapeutic strategies to prevent seizure recurrence and developmental regression.

Identifiants

DOI: 10.1016/j.eplepsyres.2021.106588 PMID: 33721708
pubmed: 33721708
pii: S0920-1211(21)00041-3
doi: 10.1016/j.eplepsyres.2021.106588
pii:
doi:

Substances chimiques

Chemokines 0
Cytokines 0
Immunomodulating Agents 0
Inflammation Mediators 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

106588

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Alessandro Orsini (A)

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Via Roma 67, 56126 Pisa, Italy.

Thomas Foiadelli (T)

Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy. Electronic address: t.foiadelli@smatteo.pv.it.

Giorgio Costagliola (G)

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Via Roma 67, 56126 Pisa, Italy.

Alexandre Michev (A)

Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy.

Rita Consolini (R)

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Via Roma 67, 56126 Pisa, Italy.

Federica Vinci (F)

Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy.

Diego Peroni (D)

Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Via Roma 67, 56126 Pisa, Italy.

Pasquale Striano (P)

Paediatric Neurology and Muscular Diseases Unit, "G. Gaslini" Institute, Via Gaslini 5, 16147 Genova, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Via Gaslini 5, 16147 Genova, Italy.

Salvatore Savasta (S)

Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The role of inflammatory mediators in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Chimiokines › The role of inflammatory mediators in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › The role of inflammatory mediators in...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › The role of inflammatory mediators in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunomodulateurs › The role of inflammatory mediators in...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › The role of inflammatory mediators in...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Maladies neuro-inflammatoires › The role of inflammatory mediators in...