Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
17
04
2020
accepted:
18
02
2021
entrez:
16
3
2021
pubmed:
17
3
2021
medline:
1
4
2021
Statut:
epublish
Résumé
Branched-chain amino acids (BCAA) and their cognate α-ketoacids (BCKA) are elevated in an array of cardiometabolic diseases. Here we demonstrate that the major metabolic fate of uniformly-
Identifiants
pubmed: 33723250
doi: 10.1038/s41467-021-21962-2
pii: 10.1038/s41467-021-21962-2
pmc: PMC7960706
doi:
Substances chimiques
Amino Acids, Branched-Chain
0
Hemiterpenes
0
Keto Acids
0
alpha-ketoisovalerate
759-05-7
Valine
HG18B9YRS7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1680Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK063720
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097441
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007101
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR069085
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR001271
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK098722
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK126160
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK125283
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK124723
Pays : United States
Organisme : NIDDK NIH HHS
ID : U2C DK119886
Pays : United States
Organisme : NHLBI NIH HHS
ID : L30 HL124508
Pays : United States
Organisme : NHLBI NIH HHS
ID : F32 HL137398
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL135275
Pays : United States
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