Idiopathic hypereosinophilic syndrome in hemodialysis patients: Case reports.
Administration, Oral
Aged, 80 and over
Diabetic Nephropathies
/ complications
Diagnosis, Differential
Dose-Response Relationship, Drug
Eosinophils
Glucocorticoids
/ administration & dosage
Humans
Hypereosinophilic Syndrome
/ blood
Leukocyte Count
Male
Middle Aged
Nephrectomy
/ adverse effects
Nephrosclerosis
/ complications
Prednisolone
/ administration & dosage
Renal Dialysis
/ adverse effects
Renal Insufficiency
/ etiology
Treatment Outcome
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
12 Mar 2021
12 Mar 2021
Historique:
received:
17
12
2020
accepted:
25
02
2021
entrez:
17
3
2021
pubmed:
18
3
2021
medline:
30
3
2021
Statut:
ppublish
Résumé
Herein, we report 3 hemodialysis patients with idiopathic hypereosinophilic syndrome who were successfully treated using corticosteroid therapy. Case 1 was a 63-year-old man who was undergoing hemodialysis because of bilateral nephrectomy and developed hypereosinophilia with digestive symptoms, myocardial injury, and intradialytic hypotension. Case 2 was an 83-year-old man who was undergoing hemodialysis because of nephrosclerosis and developed hypereosinophilia with pruritus, myocardial injury, and intradialytic hypotension. Case 3 was a 59-year-old man who was undergoing hemodialysis because of diabetic nephropathy and developed hypereosinophilia with pruritus, myocardial injury, and intradialytic hypotension. All 3 patients presented with hypereosinophilia (eosinophil count ≥1500 /μL for more than 1 month) and multiple-organ involvement (intradialytic hypotension, cardiac injury, digestive symptoms, and allergic dermatitis). A specific cause for the hypereosinophilia was not identified by systemic computed tomography, electrocardiography, echocardiography, bone marrow examination, or blood tests. Furthermore, Case 2 and 3 had not recently started taking any new drugs and drug-induced lymphocyte stimulation tests were negative in Case 1. Therefore, they were diagnosed with idiopathic hypereosinophilic syndrome. All 3 patients received corticosteroid therapy with prednisolone at a dose of 40 mg/d, 30 mg/d, and 60 mg/d in Case 1, 2, and 3, respectively. Their digestive symptoms, pruritus, intradialytic hypotension, and serum troponin I concentrations were immediately improved alongside reductions in their eosinophil counts. There have been few case reports of idiopathic hypereosinophilic syndrome in patients undergoing hemodialysis. We believe that recording of the clinical findings and treatments of such patients is mandatory to establish the optimal management of idiopathic hypereosinophilic syndrome.
Identifiants
pubmed: 33725918
doi: 10.1097/MD.0000000000025164
pii: 00005792-202103120-00112
pmc: PMC7969317
doi:
Substances chimiques
Glucocorticoids
0
Prednisolone
9PHQ9Y1OLM
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e25164Informations de copyright
Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
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