Risk assessment of dietary exposure to aflatoxin B1 in Serbia.
Adolescent
Adult
Aflatoxin B1
/ analysis
Aged
Child
Chromatography, Liquid
/ methods
Dietary Exposure
Enzyme-Linked Immunosorbent Assay
/ methods
Female
Food Contamination
/ analysis
Humans
Limit of Detection
Male
Middle Aged
Reproducibility of Results
Risk Assessment
Serbia
Tandem Mass Spectrometry
/ methods
ELISA
HCC risk
LC/MS-MS
MOE
Monte Carlo simulation
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
21
08
2020
revised:
26
02
2021
accepted:
08
03
2021
pubmed:
18
3
2021
medline:
15
9
2021
entrez:
17
3
2021
Statut:
ppublish
Résumé
Classified as Group 1 carcinogens aflatoxins (AFs) are of major concern for food safety and public health. Within the AFs group, aflatoxin B1 (AFB1) occurs at the highest levels in different food products and is considered as the most potent representative. A total of 463 samples of products susceptible to contamination with AFB1 and commonly consumed in Serbia were collected and analyzed. Consumption surveys were performed using a food frequency questionnaire (FFQ) and 24-h recall-based method. Monte Carlo simulation of 100,000 iterations was performed to estimate the intake of AFB1 through each food category, while a simple distribution approach was performed to estimate overall exposure of tested population groups. Risk characterization was performed by calculation of the Margin of Exposure (MOE) and by calculation of the number of possible hepatocellular carcinoma (HCC) cases. The highest exposure was observed in children with the mean overall estimated daily intake (EDI) in the range of 0.79-1.10 and 1.20-1.66 ng kg
Identifiants
pubmed: 33727182
pii: S0278-6915(21)00149-6
doi: 10.1016/j.fct.2021.112116
pii:
doi:
Substances chimiques
Aflatoxin B1
9N2N2Y55MH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112116Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.