Factors associated with myocardial SARS-CoV-2 infection, myocarditis, and cardiac inflammation in patients with COVID-19.
Journal
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
ISSN: 1530-0285
Titre abrégé: Mod Pathol
Pays: United States
ID NLM: 8806605
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
30
12
2020
accepted:
13
02
2021
revised:
12
02
2021
pubmed:
18
3
2021
medline:
29
6
2021
entrez:
17
3
2021
Statut:
ppublish
Résumé
COVID-19 has been associated with cardiac injury and dysfunction. While both myocardial inflammatory cell infiltration and myocarditis with myocyte injury have been reported in patients with fatal COVID-19, clinical-pathologic correlations remain limited. The objective was to determine the relationships between cardiac pathological changes in patients dying from COVID-19 and cardiac infection by SARS-CoV-2, laboratory measurements, clinical features, and treatments. In a retrospective study, 41 consecutive autopsies of patients with fatal COVID-19 were analyzed for the associations between cardiac inflammation, myocarditis, cardiac infection by SARS-CoV-2, clinical features, laboratory measurements, and treatments. Cardiac infection was assessed by in situ hybridization and NanoString transcriptomic profiling. Cardiac infection by SARS-CoV-2 was present in 30/41 cases: virus
Identifiants
pubmed: 33727695
doi: 10.1038/s41379-021-00790-1
pii: S0893-3952(22)00585-3
doi:
Substances chimiques
Anticoagulants
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1345-1357Références
JAMA Intern Med. 2021 Jan 1;181(1):24-31
pubmed: 33080005
J Vasc Surg Venous Lymphat Disord. 2021 May;9(3):592-596
pubmed: 32911110
Ann Intern Med. 2020 Aug 18;173(4):268-277
pubmed: 32374815
JAMA Cardiol. 2020 Nov 1;5(11):1281-1285
pubmed: 32730555
N Engl J Med. 2020 Dec 10;383(24):2333-2344
pubmed: 33085857
Viruses. 2020 Sep 18;12(9):
pubmed: 32962125
Cell Rep Med. 2020 Jul 21;1(4):100052
pubmed: 32835305
FASEB J. 2020 Oct;34(10):13877-13884
pubmed: 32856766
Eur Heart J. 2020 Oct 14;41(39):3827-3835
pubmed: 32968776
JAMA Intern Med. 2021 Jan 1;181(1):32-40
pubmed: 33080017
Mayo Clin Proc. 1988 Feb;63(2):137-46
pubmed: 3276974
J Am Coll Cardiol. 2020 Aug 4;76(5):533-546
pubmed: 32517963
N Engl J Med. 2021 Feb 25;384(8):693-704
pubmed: 32678530
Lancet. 2020 Aug 1;396(10247):320-332
pubmed: 32682491
N Engl J Med. 2020 Aug 6;383(6):590-592
pubmed: 32402155
JAMA. 2020 Aug 25;324(8):782-793
pubmed: 32648899
Clin Infect Dis. 2021 Nov 2;73(9):e2995-e3001
pubmed: 32856036
J Cardiovasc Electrophysiol. 2020 Dec;31(12):3077-3085
pubmed: 33017083
Forensic Sci Med Pathol. 2016 Jun;12(2):139-45
pubmed: 27020890
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Clin Infect Dis. 2020 Nov 5;71(8):1937-1942
pubmed: 32301997
J Am Soc Nephrol. 2020 Aug;31(8):1688-1695
pubmed: 32561682
JAMA. 2020 Oct 6;324(13):1307-1316
pubmed: 32876695
JAMA. 2020 Oct 6;324(13):1317-1329
pubmed: 32876697
JAMA. 2020 Oct 6;324(13):1330-1341
pubmed: 32876694
Lancet Microbe. 2020 Oct;1(6):e245-e253
pubmed: 32844161
Mod Pathol. 2020 Jan;33(1):99-108
pubmed: 31534205
Nat Commun. 2020 Oct 30;11(1):5493
pubmed: 33127906
ESC Heart Fail. 2020 Oct;7(5):2440-2447
pubmed: 32529795
Thromb Res. 2020 Dec;196:27-30
pubmed: 32823173
Eur J Clin Invest. 2009 Jul;39(7):618-25
pubmed: 19453650
JACC Clin Electrophysiol. 2020 Sep;6(9):1189-1190
pubmed: 32972558
Heart. 2021 Mar;107(5):373-380
pubmed: 33334865
Cytokine Growth Factor Rev. 2020 Jun;53:25-32
pubmed: 32446778
Cardiovasc Pathol. 2016 Nov - Dec;25(6):453-460
pubmed: 27614166
J Am Coll Cardiol. 2020 Nov 3;76(18):2043-2055
pubmed: 33121710
Methods Mol Biol. 2015;1282:1-23
pubmed: 25720466
PLoS One. 2020 Dec 22;15(12):e0244270
pubmed: 33351826