The influence of comorbid depression and overweight status on peripheral inflammation and cortisol levels.
C-Reactive Protein
CRP
Cortisoln
HPA axis
Inflammatio
Major depressive disorders
Obesity
Overweight
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
pubmed:
19
3
2021
medline:
5
1
2023
entrez:
18
3
2021
Statut:
ppublish
Résumé
Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent to which depressive symptoms and overweight status contributed to increased inflammation and abnormal cortisol levels. Participants were recruited through the Wellcome Trust NIMA Consortium. The sample of 216 participants consisted of 69 overweight patients with depression; 35 overweight controls; 55 normal-weight patients with depression and 57 normal-weight controls. Peripheral inflammation was measured as high-sensitivity C-Reactive Protein (hsCRP) in serum. Salivary cortisol was collected at multiple points throughout the day to measure cortisol awakening response and diurnal cortisol levels. Overweight patients with depression had significantly higher hsCRP compared with overweight controls ( Comorbid depression and overweight status are associated with increased hsCRP, and the coexistence of these conditions amplified the risk of clinically elevated hsCRP levels. Overweight status contributed most to the risk of clinically elevated hsCRP levels, but depression also contributed to a significant risk. We observed no differences in cortisol levels between groups.
Sections du résumé
BACKGROUND
Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent to which depressive symptoms and overweight status contributed to increased inflammation and abnormal cortisol levels.
METHODS
Participants were recruited through the Wellcome Trust NIMA Consortium. The sample of 216 participants consisted of 69 overweight patients with depression; 35 overweight controls; 55 normal-weight patients with depression and 57 normal-weight controls. Peripheral inflammation was measured as high-sensitivity C-Reactive Protein (hsCRP) in serum. Salivary cortisol was collected at multiple points throughout the day to measure cortisol awakening response and diurnal cortisol levels.
RESULTS
Overweight patients with depression had significantly higher hsCRP compared with overweight controls (
CONCLUSION
Comorbid depression and overweight status are associated with increased hsCRP, and the coexistence of these conditions amplified the risk of clinically elevated hsCRP levels. Overweight status contributed most to the risk of clinically elevated hsCRP levels, but depression also contributed to a significant risk. We observed no differences in cortisol levels between groups.
Identifiants
pubmed: 33731235
doi: 10.1017/S0033291721000088
pii: S0033291721000088
pmc: PMC9693673
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3289-3296Subventions
Organisme : Medical Research Council
ID : MR/L014815/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_G0802534
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J002739/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G108/603
Pays : United Kingdom
Organisme : MRF
ID : MRF_MRF-160-0005-ELP-MONDE
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N029488/1
Pays : United Kingdom