The influence of antibiotics on transitory resistome during gut colonization with CTX-M-15 and OXA-162 producing Klebsiella pneumoniae ST15.
Animals
Anti-Bacterial Agents
/ pharmacology
Drug Resistance, Bacterial
/ drug effects
Genome, Bacterial
/ drug effects
Humans
Klebsiella Infections
/ drug therapy
Klebsiella pneumoniae
/ drug effects
Mice
Microbial Sensitivity Tests
Plasmids
/ genetics
Whole Genome Sequencing
beta-Lactamases
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
18 03 2021
18 03 2021
Historique:
received:
23
11
2020
accepted:
16
02
2021
entrez:
19
3
2021
pubmed:
20
3
2021
medline:
13
10
2021
Statut:
epublish
Résumé
Great efforts have been made to limit the transmission of carbapenemase-producing Enterobacteriaceae (CPE), however, the intestinal reservoir of these strains and its modulation by various antibiotics remain largely unexplored. Our aim was to assess the effects of antibiotic administration (ampicillin, ceftazidime, ciprofloxacin) on the establishment and elimination of intestinal colonization with a CTX-M-15 ESBL and OXA-162 carbapenemase producing Klebsiella pneumoniae ST15 (KP5825) in a murine (C57BL/6 male mice) model. Whole genome sequencing of KP5825 strain was performed on an Illumina MiSeq platform. Conjugation assays were carried out by broth mating method. In colonization experiments, 5 × 10
Identifiants
pubmed: 33737655
doi: 10.1038/s41598-021-85766-6
pii: 10.1038/s41598-021-85766-6
pmc: PMC7973416
doi:
Substances chimiques
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
oxacillinase
EC 3.5.2.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6335Références
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