Complement component factor B has thrombin-like activity.
Coagulation diseases
Complement factor B
Infectious diseases
MBL-Associated serine protease (MASP)
Serine proteases
Thrombin
Trypsin-like domain
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
07 05 2021
07 05 2021
Historique:
received:
16
02
2021
accepted:
25
02
2021
pubmed:
20
3
2021
medline:
29
6
2021
entrez:
19
3
2021
Statut:
ppublish
Résumé
Serine proteases are fundamental components of biology, including innate immunity, which is systematically orchestrated in an orderly, balanced fashion in the healthy host. Such serine proteases are found in two well-recognized pathways of an innate immune network, coagulation and complement. Both pathways, if uncontrolled due to a variety of causes, are pathogenic in numerous diseases, including coagulation disorders and infectious diseases. Previous studies have reported sequence homologies, functional similarities and interplay between these two pathways with some implications in health and disease. The current study newly reveals that complement component factor B (Bf), the second component of the alternative complement pathway, has thrombin-like activity, which is supported by a characteristic homology of the trypsin-like domain of Bf to that of thrombin. Moreover, we newly report that the trypsin-like domain of Bf is closely related to Limulus clotting factor C, the LPS sensitive clotting factor of the innate immune system. We will also discuss potential implications of our findings in diseases.
Identifiants
pubmed: 33740660
pii: S0006-291X(21)00361-2
doi: 10.1016/j.bbrc.2021.02.134
pmc: PMC8035301
mid: NIHMS1684329
pii:
doi:
Substances chimiques
Trypsin
EC 3.4.21.4
Complement Factor B
EC 3.4.21.47
Thrombin
EC 3.4.21.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
17-22Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR051749
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI074503
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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