Alkaloids of Delphinium grandiflorum and their implication to H

Alkaloids / chemistry Apoptosis / drug effects Cardiotonic Agents / chemistry Delphinium / chemistry Diterpenes / chemistry Hydrogen Peroxide / pharmacology Myocytes, Cardiac / drug effects Plant Components, Aerial / chemistry Reactive Oxygen Species / metabolism
Antioxidant activity C(19)-diterpenoid alkaloid Delphinium grandiflorum Grandiflodines (B-12) Oxidative stress

Journal

Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298

Informations de publication

Date de publication:
01 05 2021
Historique:
received: 19 02 2021
revised: 05 03 2021
accepted: 08 03 2021
pubmed: 22 3 2021
medline: 25 9 2021
entrez: 21 3 2021
Statut: ppublish

Résumé

Three new diterpenoid alkaloids (1-3), and eight known alkaloids (4-11) were isolated from the aerial parts of Delphinium grandiflorum. Grandifline A (1) represents an unprecedented diterpenoid alkaloid ring system featuring a C-7NC17 hemiaminal moiety and a lactone fragment through the linkage of C-17OC19 unit. And we named this newly-discovered class of rearranged C

Identifiants

DOI: 10.1016/j.bmc.2021.116113 PMID: 33744825
pubmed: 33744825
pii: S0968-0896(21)00121-8
doi: 10.1016/j.bmc.2021.116113
pii:
doi:

Substances chimiques

Alkaloids 0
Cardiotonic Agents 0
Diterpenes 0
Reactive Oxygen Species 0
Hydrogen Peroxide BBX060AN9V

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116113

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Yali Wang (Y)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Dejuan Sun (D)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Yanmei Chen (Y)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Jinyu Xu (J)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Yang Xu (Y)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Xinyi Yue (X)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Jingming Jia (J)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: jiajingming@163.com.

Hua Li (H)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address: li_hua@hust.edu.cn.

Lixia Chen (L)

Wuya College of Innovation, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: syzyclx@163.com.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Cardiotoniques › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Ranunculales › Ranonculaceae › Delphinium › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Alkaloids of Delphinium grandiflorum and their...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Alkaloids of Delphinium grandiflorum and their...