Mechanisms of pallidal deep brain stimulation: Alteration of cortico-striatal synaptic communication in a dystonia animal model.

Animals Animals, Genetically Modified Cell Communication / physiology Cerebral Cortex / physiology Corpus Striatum / physiology Cricetinae Deep Brain Stimulation / instrumentation Disease Models, Animal Dystonia / physiopathology Electrodes, Implanted Excitatory Postsynaptic Potentials / physiology Globus Pallidus / physiology Mesocricetus Nerve Net / physiology Synapses / physiology
Basal ganglia Cortico-striatal projections Deep brain stimulation Dystonia Globus pallidus Inhibition Medium spiny neurones dt(sz) hamster

Journal

Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169

Informations de publication

Date de publication:
07 2021
Historique:
received: 17 11 2020
revised: 02 03 2021
accepted: 15 03 2021
pubmed: 24 3 2021
medline: 20 1 2022
entrez: 23 3 2021
Statut: ppublish

Résumé

Pallidal deep brain stimulation (DBS) is an important option for patients with severe dystonias, which are thought to arise from a disturbance in striatal control of the globus pallidus internus (GPi). The mechanisms of GPi-DBS are far from understood. Although a disturbance of striatal function is thought to play a key role in dystonia, the effects of DBS on cortico-striatal function are unknown. We hypothesised that DBS, via axonal backfiring, or indirectly via thalamic and cortical coupling, alters striatal function. We tested this hypothesis in the dt

Identifiants

DOI: 10.1016/j.nbd.2021.105341 PMID: 33753292
pubmed: 33753292
pii: S0969-9961(21)00090-5
doi: 10.1016/j.nbd.2021.105341
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105341

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Auteurs

Marco Heerdegen (M)

Oscar Langendorff Institute of Physiology, Rostock University Medical Center, Germany.

Monique Zwar (M)

Oscar Langendorff Institute of Physiology, Rostock University Medical Center, Germany.

Denise Franz (D)

Oscar Langendorff Institute of Physiology, Rostock University Medical Center, Germany.

Julia Hörnschemeyer (J)

Oscar Langendorff Institute of Physiology, Rostock University Medical Center, Germany.

Valentin Neubert (V)

Oscar Langendorff Institute of Physiology, Rostock University Medical Center, Germany.

Franz Plocksties (F)

Institute of Applied Microelectronics and Computer Engineering, Faculty of Computer Science and Electrical Engineering, University of Rostock, Germany.

Christoph Niemann (C)

Institute of Applied Microelectronics and Computer Engineering, Faculty of Computer Science and Electrical Engineering, University of Rostock, Germany.

Dirk Timmermann (D)

Institute of Applied Microelectronics and Computer Engineering, Faculty of Computer Science and Electrical Engineering, University of Rostock, Germany.

Christian Bahls (C)

Institute of General Electrical Engineering, Faculty of Computer Science and Electrical Engineering, University of Rostock, Germany.

Ursula van Rienen (U)

Institute of General Electrical Engineering, Faculty of Computer Science and Electrical Engineering, University of Rostock, Germany; Department Life, Light & Matter, University of Rostock, Germany.

Maria Paap (M)

Institute of Pharmacology, Pharmacy und Toxicology, Faculty of Veterinary Medicine, University of Leipzig, Germany.

Stefanie Perl (S)

Institute of Pharmacology, Pharmacy und Toxicology, Faculty of Veterinary Medicine, University of Leipzig, Germany.

Anika Lüttig (A)

Institute of Pharmacology, Pharmacy und Toxicology, Faculty of Veterinary Medicine, University of Leipzig, Germany.

Angelika Richter (A)

Institute of Pharmacology, Pharmacy und Toxicology, Faculty of Veterinary Medicine, University of Leipzig, Germany.

Rüdiger Köhling (R)

Oscar Langendorff Institute of Physiology, Rostock University Medical Center, Germany; Department of Ageing of Individuals and Society, University of Rostock, Germany. Electronic address: ruediger.koehling@uni-rostock.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Procédures de chirurgie opératoire › Stimulation cérébrale profonde › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Dyskinésies › Dystonie › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Électrodes implantées › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Potentiels synaptiques › Potentiels post-synaptiques excitateurs › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Noyaux gris centraux › Corps strié › Globus pallidus › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Mesocricetus › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Système nerveux › Réseau nerveux › Mechanisms of pallidal deep brain stimulation:...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Mechanisms of pallidal deep brain stimulation:...