The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome.
Blood Coagulation Disorders
/ diagnosis
C-Reactive Protein
/ analysis
COVID-19
/ complications
Female
Fibrin Fibrinogen Degradation Products
/ analysis
Heart Diseases
/ diagnosis
Hemodynamics
Heparin, Low-Molecular-Weight
/ therapeutic use
Hospital Mortality
Humans
Inflammation
Kaplan-Meier Estimate
Male
Middle Aged
Prognosis
Prospective Studies
Risk
SARS-CoV-2
/ isolation & purification
Troponin T
/ blood
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 03 2021
22 03 2021
Historique:
received:
11
10
2020
accepted:
19
02
2021
entrez:
23
3
2021
pubmed:
24
3
2021
medline:
7
4
2021
Statut:
epublish
Résumé
High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk. In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than PaO
Identifiants
pubmed: 33753759
doi: 10.1038/s41598-021-85646-z
pii: 10.1038/s41598-021-85646-z
pmc: PMC7985490
doi:
Substances chimiques
Fibrin Fibrinogen Degradation Products
0
Heparin, Low-Molecular-Weight
0
Troponin T
0
fibrin fragment D
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6515Investigateurs
Agostini O Degl'Innocenti Sabrina
(AOD)
Biancalana Martina
(B)
Borselli Matteo
(B)
Nencini Elia
(N)
Spinelli Stefano
(S)
Antognoli Rachele
(A)
Calsolario Valeria
(C)
Paterni Simone
(P)
Baldassarri Rubia
(B)
Bertini Pietro
(B)
Brizzi Giulia
(B)
Corradi Francesco
(C)
Della Rocca Alessandra
(DR)
Guarracino Fabio
(G)
Malacarne Paolo
(M)
Monfroni Marco
(M)
Piagnani Chiara
(P)
Celi Alessandro
(C)
Cinotti Francesco
(C)
Park Naria
(P)
Cipriano Alessandro
(C)
Colangelo Luciano
(C)
Sonato Chiara
(S)
Galfo Valentina
(G)
Monica Uliana
(M)
Ruberti Francesca
(R)
Forotti Giovanna
(F)
Sciuto Maria
(S)
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