Cognitive impairment and its neuroimaging correlates in spinocerebellar ataxia 2.
Cerebellum
Cognitive impairment
Grey matter
SCA2
Spinocerebellar ataxia
Journal
Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
05
11
2020
revised:
04
02
2021
accepted:
22
02
2021
pubmed:
24
3
2021
medline:
6
1
2022
entrez:
23
3
2021
Statut:
ppublish
Résumé
Cognitive impairment (CI) is reported but is poorly explored in spinocerebellar ataxia 2 (SCA2). This study was undertaken to evaluate and classify cognitive impairment in patients with SCA2 and to identify their grey matter (GM) correlates. We evaluated the neurocognitive profile of 35 SCA2 and 30 age-, gender- and education-matched healthy controls using tests for attention, executive functions, learning and memory, language and fluency, and visuomotor constructive ability. Patients were classified into SCA2 with and without CI based on normative data from population and healthy controls. Furthermore, patients with CI were sub-classified based on the number of impaired domains into multi-domain CI (≥3 domains; MDCI) and limited domain CI (≤2 domains; LDCI). The underlying GM changes were identified using voxel based morphometry. The mean age at onset, duration of disease, and ataxia score was 28.7 ± 8.51 years, 66.7 ± 44.1 months, and 16.1 ± 4.9 points, respectively. CI was present in 71.4% of SCA2 subjects (MDCI: 42.7%; LDCI: 28.5%). Patients with CI had significant atrophy of the posterior cerebellum, sensorimotor cortex, and superior frontal gyrus (FWE p-value <0.05). Patients with MDCI had significant GM atrophy of the angular gyrus compared to LDCI (FWE p-value <0.05). Patients with CI had significant GM involvement of the posterior cerebellum and frontal lobe, suggestive of impairment in the cerebello-fronto-cortical circuitry.
Identifiants
pubmed: 33756405
pii: S1353-8020(21)00077-8
doi: 10.1016/j.parkreldis.2021.02.028
pmc: PMC7613150
mid: EMS150888
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-83Subventions
Organisme : DBT-Wellcome Trust India Alliance
ID : IA/CPHI/17/1/503348
Pays : India
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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