Molecular Basis for Bordetella pertussis Interference with Complement, Coagulation, Fibrinolytic, and Contact Activation Systems: the Cryo-EM Structure of the Vag8-C1 Inhibitor Complex.

Bacterial Proteins / chemistry Binding Sites Blood Coagulation Bordetella pertussis / chemistry Complement C1 Inhibitor Protein / chemistry Complement System Proteins / metabolism Cryoelectron Microscopy Fibrinolysis Immune Evasion Models, Molecular Mutation Protein Binding Protein Domains Type V Secretion Systems / genetics Virulence Virulence Factors, Bordetella
Bordetella pertussis C1-INH autotransporters bacterial pathogenicity complement system immune evasion serpin single-particle cryo-EM three-dimensional structure

Journal

mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231

Informations de publication

Date de publication:
23 03 2021
Historique:
entrez: 24 3 2021
pubmed: 25 3 2021
medline: 10 4 2021
Statut: epublish

Résumé

Complement, contact activation, coagulation, and fibrinolysis are serum protein cascades that need strict regulation to maintain human health. Serum glycoprotein, a C1 inhibitor (C1-INH), is a key regulator (inhibitor) of serine proteases of all the above-mentioned pathways. Recently, an autotransporter protein, virulence-associated gene 8 (Vag8), produced by the whooping cough pathogen,

Identifiants

DOI: 10.1128/mBio.02823-20 PMID: 33758081 PMC: PMC8092270
pubmed: 33758081
pii: mBio.02823-20
doi: 10.1128/mBio.02823-20
pmc: PMC8092270
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Complement C1 Inhibitor Protein 0
SERPING1 protein, human 0
Type V Secretion Systems 0
Vag8, Bordetella pertussis 0
Virulence Factors, Bordetella 0
Complement System Proteins 9007-36-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
ID : 219477
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209194
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100298
Pays : United Kingdom
Organisme : Medical Research Council
ID : S007474
Pays : United Kingdom

Informations de copyright

Copyright © 2021 Dhillon et al.

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Auteurs

Arun Dhillon (A)

Sir William Dunn School of Pathology, Oxford, United Kingdom.

Justin C Deme (JC)

Sir William Dunn School of Pathology, Oxford, United Kingdom.
Central Oxford Structural Molecular Imaging Centre, Oxford, United Kingdom.

Emily Furlong (E)

Sir William Dunn School of Pathology, Oxford, United Kingdom.

Dorina Roem (D)

Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Amsterdam University Medical Centre, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands.

Ilse Jongerius (I)

Sanquin Research, Department of Immunopathology, and Landsteiner Laboratory, Amsterdam University Medical Centre, Amsterdam Infection and Immunity Institute, Amsterdam, the Netherlands.
Department of Pediatric Immunology, Rheumatology, and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, the Netherlands.

Steven Johnson (S)

Sir William Dunn School of Pathology, Oxford, United Kingdom steven.johnson@path.ox.ac.uk susan.lea@path.ox.ac.uk.

Susan M Lea (SM)

Sir William Dunn School of Pathology, Oxford, United Kingdom steven.johnson@path.ox.ac.uk susan.lea@path.ox.ac.uk.
Central Oxford Structural Molecular Imaging Centre, Oxford, United Kingdom.
ORCID: 0000-0001-9287-8053

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Bactéries › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › Bordetella pertussis › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines inhibitrices de la fraction C1 du complément › C1 Inhibiteur › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Immunoprotéines › Protéines du système du complément › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Cryomicroscopie électronique › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Coagulation sanguine › Fibrinolyse › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Phénomènes biologiques › Interactions hôte-microbes › Interactions hôte-pathogène › Échappement immunitaire › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Systèmes de translocation des protéines › Systèmes bactériens de sécrétion › Systèmes de sécrétion de type V › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Phénomènes microbiologiques › Virulence › Molecular Basis for Bordetella pertussis...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Facteurs de virulence › Facteurs de virulence des Bordetella › Molecular Basis for Bordetella pertussis...