Phosphoglycerate dehydrogenase genes differentially affect Arabidopsis metabolism and development.


Journal

Plant science : an international journal of experimental plant biology
ISSN: 1873-2259
Titre abrégé: Plant Sci
Pays: Ireland
ID NLM: 9882015

Informations de publication

Date de publication:
May 2021
Historique:
received: 16 11 2020
revised: 25 02 2021
accepted: 25 02 2021
entrez: 29 3 2021
pubmed: 30 3 2021
medline: 15 4 2021
Statut: ppublish

Résumé

Unlike animals, plants possess diverse L-serine (Ser) biosynthetic pathways. One of them, the Phosphorylated Pathway of Serine Biosynthesis (PPSB) has been recently described as essential for embryo, pollen and root development, and required for ammonium and sulfur assimilation. The first and rate limiting step of PPSB is the reaction catalyzed by the enzyme phosphoglycerate dehydrogenase (PGDH). In Arabidopsis, the PGDH family consists of three genes, PGDH1, PGDH2 and PGDH3. PGDH1 is characterized as being the essential gene of the family. However, the biological significance of PGDH2 and PGDH3 remains unknown. In this manuscript, we have functionally characterized PGDH2 and PGDH3. Phenotypic, metabolomic and gene expression analysis in PGDH single, double and triple mutants indicate that both PGDH2 and PGDH3 are functional, affecting plant metabolism and development. PGDH2 has a stronger effect on plant growth than PGDH3, having a partial redundant role with PGDH1. PGDH3, however, could have additional functions in photosynthetic cells unrelated to Ser biosynthesis.

Identifiants

pubmed: 33775368
pii: S0168-9452(21)00052-2
doi: 10.1016/j.plantsci.2021.110863
pii:
doi:

Substances chimiques

Serine 452VLY9402
Phosphoglycerate Dehydrogenase EC 1.1.1.95

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110863

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Rubén Casatejada-Anchel (R)

Departament de Biologia Vegetal, Facultat de Farmàcia, Universitat de València, 46100, Burjassot, Spain; Institut de Biotecnologia i Biomedicina (BIOTECMED), Universitat de València, 46100, Burjassot, Spain. Electronic address: Ruben.Casatejada@uv.es.

Jesús Muñoz-Bertomeu (J)

Departament de Biologia Vegetal, Facultat de Farmàcia, Universitat de València, 46100, Burjassot, Spain. Electronic address: Jesus.Munoz-Bertomeu@uv.es.

Sara Rosa-Téllez (S)

Departament de Biologia Vegetal, Facultat de Farmàcia, Universitat de València, 46100, Burjassot, Spain; Institut de Biotecnologia i Biomedicina (BIOTECMED), Universitat de València, 46100, Burjassot, Spain. Electronic address: Sara.Rosa@uv.es.

Armand D Anoman (AD)

Departament de Biologia Vegetal, Facultat de Farmàcia, Universitat de València, 46100, Burjassot, Spain; Institut de Biotecnologia i Biomedicina (BIOTECMED), Universitat de València, 46100, Burjassot, Spain. Electronic address: Armand.Anoman@uv.es.

Sergio G Nebauer (SG)

Departamento de Producción vegetal, Universitat Politècnica de València, 46022, Valencia, Spain. Electronic address: sergonne@bvg.upv.es.

Alejandro Torres-Moncho (A)

Departament de Biologia Vegetal, Facultat de Farmàcia, Universitat de València, 46100, Burjassot, Spain; Institut de Biotecnologia i Biomedicina (BIOTECMED), Universitat de València, 46100, Burjassot, Spain. Electronic address: Alejandro.torres-moncho@uv.es.

Alisdair R Fernie (AR)

Max Planck Institut für Molekulare Pflanzenphysiologie, 14476, Potsdam-Golm, Germany. Electronic address: Fernie@mpimp-golm.mpg.de.

Roc Ros (R)

Departament de Biologia Vegetal, Facultat de Farmàcia, Universitat de València, 46100, Burjassot, Spain; Institut de Biotecnologia i Biomedicina (BIOTECMED), Universitat de València, 46100, Burjassot, Spain. Electronic address: roc.ros@uv.es.

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Classifications MeSH