The association of three DNA repair genes polymorphisms on the frequency of chromosomal alterations detected by fluorescence in situ hybridization.
Adult
Ataxia Telangiectasia Mutated Proteins
/ genetics
Brazil
Checkpoint Kinase 2
/ genetics
Chromosome Aberrations
Cross-Sectional Studies
DNA Repair
/ genetics
Female
Gasoline
Genotype
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Occupational Exposure
Oil and Gas Industry
Polymorphism, Genetic
Rad51 Recombinase
/ genetics
Young Adult
ATM/P1054R
Benzene
Chromosome aberration
Gas station worker
RAD51/G135C
Journal
International archives of occupational and environmental health
ISSN: 1432-1246
Titre abrégé: Int Arch Occup Environ Health
Pays: Germany
ID NLM: 7512134
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
19
06
2020
accepted:
07
01
2021
pubmed:
30
3
2021
medline:
24
9
2021
entrez:
29
3
2021
Statut:
ppublish
Résumé
Gas station workers (GSWs) are exposed to carcinogenic agents. The aim was to study the association of high somatic chromosome alterations (CAs) rates in the blood of GSWs and the polymorphisms of three genes playing a role in DNA double-strand break repair. This is a cross-sectional study with 114 GSWs and 115 age-matched controls. Cytogenetic analyses, blood exams, medical interviews and genotypes for RAD51/G135C (rs1801320), ATM/P1054R (rs1800057) and CHEK2/T470C (rs17879961) genes were performed. The CA rate in GSWs was 9.8 CAs/1000 metaphases, and 19.1% of the workers had > 10 CAs per 1000 metaphases (group two). GSWs had decreased levels of monocytes (P = 0.024) in their blood exams. The number of variant alleles of the RAD51/G135C polymorphism was higher in GSWs (P = 0.011) compared to the controls, and were associated with enhanced number of CAs per worker (P = 0.008). No allele variant was found for CHEK2/T470C in this study. The RAD51/G135C polymorphism appears to be related to genome instability in gas station workers. Increasing the knowledge of DNA repair gene variations involved in maintaining genomic stability in GSWs may be crucial for future cancer prevention.
Identifiants
pubmed: 33778923
doi: 10.1007/s00420-021-01652-8
pii: 10.1007/s00420-021-01652-8
pmc: PMC8384795
doi:
Substances chimiques
Gasoline
0
Checkpoint Kinase 2
EC 2.7.1.11
ATM protein, human
EC 2.7.11.1
Ataxia Telangiectasia Mutated Proteins
EC 2.7.11.1
CHEK2 protein, human
EC 2.7.11.1
RAD51 protein, human
EC 2.7.7.-
Rad51 Recombinase
EC 2.7.7.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1567-1577Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021. The Author(s).
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