The intestinal microbiota and metabolites in patients with anorexia nervosa.
Adult
Anorexia Nervosa
/ metabolism
Archaea
/ classification
Bacteria
/ classification
Body Mass Index
Brain-Gut Axis
Fatty Acids, Volatile
/ metabolism
Feces
/ microbiology
Female
Fungi
/ classification
Gastrointestinal Microbiome
Humans
Longitudinal Studies
Metagenome
Mycobiome
Neurotransmitter Agents
/ metabolism
Young Adult
BMI
EDE-Q
Microbiome
SCFA
bacteriome
dysbiosis
gut-brain-microbiota axis
mycobiome
neurotransmitter
renourishment
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
Historique:
entrez:
29
3
2021
pubmed:
30
3
2021
medline:
8
1
2022
Statut:
ppublish
Résumé
Brain-gut microbiota interactions are intensively studied in connection with various neurological and psychiatric diseases. While anorexia nervosa (AN) pathophysiology is not entirely clear, it is presumably linked to microbiome dysbiosis. We aimed to elucidate the gut microbiota contribution in AN disease pathophysiology. We analyzed the composition and diversity of the gut microbiome of patients with AN (bacteriome and mycobiome) from stool samples before and after renourishment, and compared them to healthy controls. Further, levels of assorted neurotransmitters and short-chain fatty acids (SCFA) were analyzed in stool samples by MS and NMR, respectively. Biochemical, anthropometric, and psychometric profiles were assessed. The bacterial alpha-diversity parameter analyses revealed only increased Chao 1 index in patients with AN before the realimentation, reflecting their interindividual variation. Subsequently, core microbiota depletion signs were observed in patients with AN. Overrepresented OTUs (operation taxonomic units) in patients with AN taxonomically belonged to
Identifiants
pubmed: 33779487
doi: 10.1080/19490976.2021.1902771
pmc: PMC8018350
doi:
Substances chimiques
Fatty Acids, Volatile
0
Neurotransmitter Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-25Références
Int J Eat Disord. 1994 Dec;16(4):363-70
pubmed: 7866415
Microbiome. 2017 Nov 25;5(1):153
pubmed: 29178920
Clin Nutr. 2019 Oct;38(5):2304-2310
pubmed: 30527539
PLoS One. 2013 Apr 22;8(4):e61217
pubmed: 23630581
Appl Environ Microbiol. 2007 Aug;73(16):5261-7
pubmed: 17586664
Eur Eat Disord Rev. 2016 Sep;24(5):417-24
pubmed: 27045727
J Clin Gastroenterol. 2006 Mar;40(3):235-43
pubmed: 16633129
Gastroenterology. 1980 Jun;78(6):1500-7
pubmed: 6768637
PeerJ. 2016 Oct 18;4:e2584
pubmed: 27781170
PLoS One. 2009 Sep 23;4(9):e7125
pubmed: 19774074
J Lipid Res. 2013 Sep;54(9):2325-40
pubmed: 23821742
Psychiatry Res. 2015 Sep 30;229(1-2):37-48
pubmed: 26296951
Sci Rep. 2016 May 27;6:26752
pubmed: 27229737
PLoS One. 2017 Jun 21;12(6):e0179739
pubmed: 28636668
Int J Obes (Lond). 2013 Nov;37(11):1460-6
pubmed: 23459324
Anal Chem. 2006 Jul 1;78(13):4281-90
pubmed: 16808434
FEMS Microbiol Ecol. 2012 Dec;82(3):666-77
pubmed: 22738186
Gut Pathog. 2018 Jan 25;10:3
pubmed: 29416567
Nat Rev Immunol. 2017 Apr;17(4):219-232
pubmed: 28260787
Trends Pharmacol Sci. 2005 Jan;26(1):36-43
pubmed: 15629203
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Nat Methods. 2016 Jul;13(7):581-3
pubmed: 27214047
Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209
pubmed: 25830558
Brain Behav Immun. 2015 Aug;48:186-94
pubmed: 25882912
Genome Biol. 2014;15(12):550
pubmed: 25516281
Bioinformatics. 2014 May 1;30(9):1312-3
pubmed: 24451623
PLoS One. 2015 Dec 18;10(12):e0145274
pubmed: 26682545
BMC Bioinformatics. 2014 Jun 12;15:182
pubmed: 24925680
Science. 2012 Jun 8;336(6086):1262-7
pubmed: 22674330
Nat Microbiol. 2017 Aug 24;2:17121
pubmed: 28836573
Nucleic Acids Res. 2019 Jan 8;47(D1):D259-D264
pubmed: 30371820
Cell. 2014 Nov 6;159(4):789-99
pubmed: 25417156
Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4516-22
pubmed: 20534432
Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6
pubmed: 23193283
Nutrients. 2018 Feb 28;10(3):
pubmed: 29495552
BMC Genomics. 2013 Sep 14;14:623
pubmed: 24034898
Clin Nutr. 2021 Mar;40(3):1137-1146
pubmed: 32782162
Psychosom Med. 2015 Nov-Dec;77(9):969-81
pubmed: 26428446
Microorganisms. 2019 Sep 10;7(9):
pubmed: 31510101
Clin Nutr. 2020 Mar;39(3):676-684
pubmed: 30952533
CNS Neurol Disord Drug Targets. 2016;15(1):35-44
pubmed: 26295824
BMC Bioinformatics. 2011 Sep 30;12:385
pubmed: 21961884
FEMS Microbiol Rev. 2017 Mar 1;41(2):182-199
pubmed: 28364729
Genome Med. 2016 Apr 27;8(1):51
pubmed: 27122046
Nat Rev Neurosci. 2009 Aug;10(8):573-84
pubmed: 19603056
Front Immunol. 2020 Jun 09;11:906
pubmed: 32582143
Neurotherapeutics. 2018 Jan;15(1):156-175
pubmed: 29340929
PLoS One. 2013 Jun 17;8(6):e66019
pubmed: 23799070
PLoS Comput Biol. 2009 Aug;5(8):e1000465
pubmed: 19680427
FEMS Microbiol Rev. 2015 Jul;39(4):509-21
pubmed: 25701044
Bioinformatics. 2011 Aug 15;27(16):2194-200
pubmed: 21700674
Int J Eat Disord. 2017 Dec;50(12):1421-1431
pubmed: 29131365