The Future of Blood Testing Is the Immunome.

Adaptive Immunity Hematologic Tests / trends High-Throughput Nucleotide Sequencing Humans Receptors, Antigen, T-Cell / immunology
T-cell receptor repertoire adaptive immune receptor repertoire (AIRR) analyses antibody repertoire clinical laboratory testing diagnostic test immunome immunomics

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 06 11 2020
accepted: 19 01 2021
entrez: 1 4 2021
pubmed: 2 4 2021
medline: 21 9 2021
Statut: epublish

Résumé

It is increasingly clear that an extraordinarily diverse range of clinically important conditions-including infections, vaccinations, autoimmune diseases, transplants, transfusion reactions, aging, and cancers-leave telltale signatures in the millions of V(D)J-rearranged antibody and T cell receptor [TR per the Human Genome Organization (HUGO) nomenclature but more commonly known as TCR] genes collectively expressed by a person's B cells (antibodies) and T cells. We refer to these as the

Identifiants

DOI: 10.3389/fimmu.2021.626793 PMID: 33790897 PMC: PMC8005722
pubmed: 33790897
doi: 10.3389/fimmu.2021.626793
pmc: PMC8005722
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

626793

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI148747
Pays : United States

Investigateurs

Ramy A Arnaout (RA)
Rohit Arora (R)
Rachael Bashford-Rogers (R)
Felix Breden (F)
Syed Ahmad Chan Bukhari (SAC)
Brian Corrie (B)
Lindsay G Cowell (LG)
Sol Efroni (S)
Christopher Gooley (C)
Victor Greiff (V)
Jason Vander Heiden (JV)
Yoshinobu Koguchi (Y)
Ton Langerak (T)
Theam Soon Lim (TS)
Eline Luning Prak (EL)
Encarnita Mariotti-Ferrandiz (E)
Susanna Marquez (S)
Pieter Meysman (P)
Enkelejda Miho (E)
Keshav Motwani (K)
Nima Nouri (N)
Milena Pavlović (M)
Florian Rubelt (F)
Geir Kjetil Sandve (GK)
Nicholas Schwab (N)
Igor Snapkov (I)
Cinque Soto (C)
Ulrik Stervbo (U)
Johannes Trück (J)
Henk-Jan van den Ham (HJ)
Corey Watson (C)
Cédric R Weber (CR)

Informations de copyright

Copyright © 2021 Arnaout, Prak, Schwab, Rubelt and the Adaptive Immune Receptor Repertoire Community.

Déclaration de conflit d'intérêts

Author FR was employed by Roche Sequencing Solutions. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Ramy A Arnaout (RA)

Department of Pathology and Division of Clinical Informatics, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Department of Pathology, Harvard Medical School, Boston, MA, United States.

Eline T Luning Prak (ETL)

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.

Nicholas Schwab (N)

Department of Neurology and Institute of Translational Neurology, University of Muenster, Muenster, Germany.

Florian Rubelt (F)

Roche Sequencing Solutions, Pleasanton, CA, United States.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › The Future of Blood Testing Is the Immunome.
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests hématologiques › The Future of Blood Testing Is the Immunome.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › The Future of Blood Testing Is the Immunome.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Future of Blood Testing Is the Immunome.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › The Future of Blood Testing Is the Immunome.