Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways.
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 06 2021
15 06 2021
Historique:
received:
03
12
2020
revised:
05
02
2021
accepted:
29
03
2021
pubmed:
3
4
2021
medline:
8
4
2022
entrez:
2
4
2021
Statut:
ppublish
Résumé
To delineate recurrent oncogenic driver alterations and dysregulated pathways in esophageal adenocarcinoma and to assess their prognostic value. We analyzed a large cohort of patients with lower esophageal and junctional adenocarcinoma, prospectively sequenced by MSK-IMPACT with high-quality clinical annotation. Patients were subdivided according to treatment intent, curative versus palliative, which closely mirrored clinical staging. Genomic features, alterations, and pathways were examined for association with overall survival using Cox proportional hazard models, adjusted for relevant clinicopathologic factors knowable at the time of diagnosis. Analysis of 487 patients revealed 16 oncogenic driver alterations, mostly amplifications, present in ≥5% of patients. Patients in the palliative-intent cohort, compared with those in the curative-intent cohort, were more likely to have metastatic disease, Our study suggests that higher levels of genomic instability are associated with more advanced disease in esophageal adenocarcinoma. Furthermore,
Identifiants
pubmed: 33795256
pii: 1078-0432.CCR-20-4707
doi: 10.1158/1078-0432.CCR-20-4707
pmc: PMC8228505
mid: NIHMS1691679
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3491-3498Subventions
Organisme : NCI NIH HHS
ID : K12 CA184746
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA217169
Pays : United States
Informations de copyright
©2021 American Association for Cancer Research.
Références
Oncotarget. 2016 Mar 1;7(9):10051-63
pubmed: 26840267
Arch Pathol Lab Med. 2016 Dec;140(12):1345-1363
pubmed: 27841667
JCO Precis Oncol. 2017 Jul;2017:
pubmed: 28890946
Nat Med. 2017 Jun;23(6):703-713
pubmed: 28481359
Cancer Discov. 2012 May;2(5):401-4
pubmed: 22588877
JCO Precis Oncol. 2017;2017:
pubmed: 30211344
J Natl Compr Canc Netw. 2019 Jul 1;17(7):855-883
pubmed: 31319389
Cancer Discov. 2018 Jan;8(1):49-58
pubmed: 29122777
J Clin Oncol. 2006 Sep 10;24(26):4347-55
pubmed: 16963732
Ann Cardiothorac Surg. 2017 Mar;6(2):119-130
pubmed: 28447000
Lancet. 2010 Aug 28;376(9742):687-97
pubmed: 20728210
Clin J Gastroenterol. 2020 Dec;13(6):1010-1021
pubmed: 32965635
Nucleic Acids Res. 2016 Sep 19;44(16):e131
pubmed: 27270079
Nat Genet. 2013 May;45(5):478-86
pubmed: 23525077
Dis Esophagus. 2016 Nov;29(8):897-905
pubmed: 27905172
Cancer Cell Int. 2019 Aug 22;19:216
pubmed: 31440117
Nature. 2017 Jan 12;541(7636):169-175
pubmed: 28052061
Nat Genet. 2018 Aug;50(8):1189-1195
pubmed: 30013179
Cancer Treat Rev. 2020 Jun;86:102024
pubmed: 32388292
Nat Genet. 2016 Oct;48(10):1131-41
pubmed: 27595477
Cancer. 2019 Jun 15;125(12):1990-2001
pubmed: 30973648
J Clin Oncol. 2013 Dec 10;31(35):4445-52
pubmed: 24127447
Gut. 2017 Mar;66(3):399-410
pubmed: 26733670
Nat Genet. 2020 Jan;52(1):74-83
pubmed: 31907488
J Thorac Cardiovasc Surg. 2018 Aug;156(2):847-856
pubmed: 30011772
Nat Rev Clin Oncol. 2018 Mar;15(3):139-150
pubmed: 29297505
Genome Res. 2012 Feb;22(2):398-406
pubmed: 21908773
Sci Signal. 2013 Apr 02;6(269):pl1
pubmed: 23550210
Cell. 2018 Apr 5;173(2):321-337.e10
pubmed: 29625050
Nat Genet. 2019 Mar;51(3):506-516
pubmed: 30718927
Nat Genet. 2019 Feb;51(2):202-206
pubmed: 30643254
Cancer Discov. 2018 Feb;8(2):174-183
pubmed: 29247016
J Mol Diagn. 2015 May;17(3):251-64
pubmed: 25801821
Nat Med. 2018 Jul;24(7):968-977
pubmed: 29808010
Am J Surg Pathol. 2015 Apr;39(4):487-95
pubmed: 25634752