Association Between Hemostatic Profile and Migraine: A Mendelian Randomization Analysis.

Case-Control Studies Factor VII / metabolism Factor VIII / metabolism Factor XI / metabolism Fibrin Fibrinogen Degradation Products / metabolism Fibrinogen / metabolism Fibrinopeptide A / metabolism Genetic Predisposition to Disease Genome-Wide Association Study Hemostasis / genetics Humans International Normalized Ratio Mendelian Randomization Analysis Migraine Disorders / blood Migraine with Aura / blood Migraine without Aura / blood Partial Thromboplastin Time Plasminogen Activator Inhibitor 1 / blood Prothrombin Time Tissue Plasminogen Activator / blood von Willebrand Factor / metabolism

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
18 05 2021
Historique:
received: 27 08 2020
accepted: 24 02 2021
pubmed: 3 4 2021
medline: 1 6 2021
entrez: 2 4 2021
Statut: ppublish

Résumé

To assess support for a causal relationship between hemostatic measures and migraine susceptibility using genetic instrumental analysis. Two-sample Mendelian randomization instrumental analyses leveraging available genome-wide association study (GWAS) summary statistics were applied to hemostatic measures as potentially causal for migraine and its subtypes, migraine with aura (MA) and migraine without aura (MO). Twelve blood-based measures of hemostasis were examined, including plasma level or activity of 8 hemostatic factors and 2 fibrinopeptides together with 2 hemostasis clinical tests. There were significant instrumental effects between increased coagulation factor VIII activity (FVIII; odds ratio [95% confidence interval] 1.05 [1.03, 1.08]/SD, The findings support potential causality of increased FVIII, vWF, and phosphorylated fibrinopeptide A and decreased fibrinogen in migraine susceptibility, especially for MA, potentially revealing etiologic relationships between hemostasis and migraine.

Identifiants

DOI: 10.1212/WNL.0000000000011931 PMID: 33795393 PMC: PMC8205479
pubmed: 33795393
pii: WNL.0000000000011931
doi: 10.1212/WNL.0000000000011931
pmc: PMC8205479
doi:

Substances chimiques

Fibrin Fibrinogen Degradation Products 0
Plasminogen Activator Inhibitor 1 0
fibrin fragment D 0
fibrinopeptide A, phospho-Ser(3)- 0
von Willebrand Factor 0
Fibrinopeptide A 25422-31-5
Factor VII 9001-25-6
Factor VIII 9001-27-8
Fibrinogen 9001-32-5
Factor XI 9013-55-2
Tissue Plasminogen Activator EC 3.4.21.68

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2481-e2487

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL139553
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS104398
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL128791
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141291
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134894
Pays : United States

Informations de copyright

© 2021 American Academy of Neurology.

Références

BMJ. 2018 Jul 12;362:k601
pubmed: 30002074
Neurol Sci. 2014 Apr;35(4):545-9
pubmed: 24057117
Nature. 2005 Oct 27;437(7063):1299-320
pubmed: 16255080
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Hum Mol Genet. 2016 Jan 15;25(2):358-70
pubmed: 26561523
Headache. 2020 May;60(5):843-863
pubmed: 32246455
Cephalalgia. 2008 Jan;28(1):49-56
pubmed: 17986270
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Eur J Epidemiol. 2018 Oct;33(10):947-952
pubmed: 30039250
Arterioscler Thromb Vasc Biol. 2014 May;34(5):1093-101
pubmed: 24578379
Indian J Anaesth. 2014 Sep;58(5):515-23
pubmed: 25535411
Am J Hum Genet. 2012 Jul 13;91(1):152-62
pubmed: 22703881
Nat Genet. 2016 Aug;48(8):856-66
pubmed: 27322543
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
Cephalalgia. 2015 Feb;35(2):95-117
pubmed: 25281220
Nat Genet. 2014 Jun;46(6):543-550
pubmed: 24816252
Cephalalgia. 2013 Mar;33(4):228-35
pubmed: 23147163
BMJ Open. 2018 Mar 27;8(3):e020498
pubmed: 29593023
Headache. 2018 Jan;58(1):173-183
pubmed: 28181217
Circulation. 2011 May 3;123(17):1864-72
pubmed: 21502573
Blood. 2019 Feb 28;133(9):967-977
pubmed: 30642921
Arterioscler Thromb Vasc Biol. 2001 May;21(5):731-8
pubmed: 11348867
Acta Neurol Scand. 1995 May;91(5):412-3
pubmed: 7639074
Elife. 2018 May 30;7:
pubmed: 29846171
J Clin Invest. 1976 Nov;58(5):1136-44
pubmed: 993337
J Am Coll Cardiol. 1989 Sep;14(3):597-603
pubmed: 2768709
Hum Mol Genet. 2017 Feb 1;26(3):637-649
pubmed: 28053049
Neurology. 2001 Jul 24;57(2):334-6
pubmed: 11468324
Circulation. 2019 Jan 29;139(5):620-635
pubmed: 30586737
Nat Commun. 2018 Jan 15;9(1):224
pubmed: 29335400
Lancet Neurol. 2010 Mar;9(3):309-17
pubmed: 20170844
Pathophysiol Haemost Thromb. 2003 Sep-2004 Dec;33(5-6):302-8
pubmed: 15692233
JAMA. 2020 Jun 9;323(22):2281-2289
pubmed: 32515815
Artery. 1996;22(2):93-100
pubmed: 8864251
Cephalalgia. 2018 Mar;38(3):511-518
pubmed: 28885052
Stroke. 2009 Sep;40(9):2977-82
pubmed: 19608996
Thromb Res. 1985 Oct 1;40(1):29-39
pubmed: 4089825
Blood. 2012 Dec 6;120(24):4873-81
pubmed: 22990020

Auteurs

Yanjun Guo (Y)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany.

Pamela M Rist (PM)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0003-3543-045X

Maria Sabater-Lleal (M)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0002-0128-379X

Paul de Vries (P)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0003-0964-0111

Nicholas Smith (N)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany.

Paul M Ridker (PM)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0003-1249-4522

Tobias Kurth (T)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany.
ORCID: 0000-0001-7169-2620

Daniel I Chasman (DI)

From the Division of Preventive Medicine (Y.G., P.M. Rist, P.M. Ridker, D.C.), Brigham and Women's Hospital; Harvard Medical School (Y.G., P.M. Rist, P.M. Ridker, D.I.C.); Department of Epidemiology (Y.G., P.M. Rist, P.M. Ridker, T.K., D.C.), Harvard T.H. Chan School of Public Health, Boston, MA; Genomics of Complex Diseases (M.S.-L.), Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain; Cardiovascular Medicine Unit, Department of Medicine (M.S.-L.), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences (P.d.V.), School of Public Health, The University of Texas Health Science Center at Houston; Department of Epidemiology (N.S.), University of Washington; Kaiser Permanente Washington Health Research Institute (N.S.), Seattle; Seattle Epidemiologic Research and Information Center (N.S.), Department of Veterans Affairs Office of Research and Development, WA; and Institute of Public Health (T.K.), Charité-Universitätsmedizin Berlin, Germany. dchasman@research.bwh.harvard.edu.
ORCID: 0000-0003-3357-0862

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur VII › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur VIII › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur XI › Association Between Hemostatic Profile and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Précurseurs de protéines › Produits de dégradation de la fibrine et du fibrinogène › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Fibrinogène › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Fibrinopeptide A › Association Between Hemostatic Profile and...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Association Between Hemostatic Profile and...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Association Between Hemostatic Profile and...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Association Between Hemostatic Profile and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association Between Hemostatic Profile and...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Tests hématologiques › Tests de coagulation sanguine › Rapport international normalisé › Association Between Hemostatic Profile and...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Association Between Hemostatic Profile and...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Association Between Hemostatic Profile and...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Migraine avec aura › Association Between Hemostatic Profile and...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Céphalées › Céphalées primitives › Migraines › Migraine sans aura › Association Between Hemostatic Profile and...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Temps partiel de thromboplastine › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Inhibiteurs d'activateurs du plasminogène › Inhibiteur-1 d'activateur du plasminogène › Association Between Hemostatic Profile and...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Temps de prothrombine › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Activateur tissulaire du plasminogène › Association Between Hemostatic Profile and...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Facteur de von Willebrand › Association Between Hemostatic Profile and...