Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice.
Administration, Oral
Aging
/ physiology
Animals
Antiparkinson Agents
/ administration & dosage
Auditory Threshold
/ drug effects
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem
/ drug effects
Hearing Loss, Sensorineural
/ drug therapy
Humans
Male
Mice, Inbred BALB C
Mice, Inbred DBA
Protective Agents
/ administration & dosage
Selegiline
/ administration & dosage
Synaptic Transmission
/ drug effects
age-related hearing loss
chronic oral treatment
hearing protection
mouse model
selegiline
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
11 Mar 2021
11 Mar 2021
Historique:
received:
25
01
2021
revised:
05
03
2021
accepted:
09
03
2021
entrez:
3
4
2021
pubmed:
4
4
2021
medline:
4
5
2021
Statut:
epublish
Résumé
Age-related hearing loss (ARHL), a sensorineural hearing loss of multifactorial origin, increases its prevalence in aging societies. Besides hearing aids and cochlear implants, there is no FDA approved efficient pharmacotherapy to either cure or prevent ARHL. We hypothesized that selegiline, an antiparkinsonian drug, could be a promising candidate for the treatment due to its complex neuroprotective, antioxidant, antiapoptotic, and dopaminergic neurotransmission enhancing effects. We monitored by repeated Auditory Brainstem Response (ABR) measurements the effect of chronic per os selegiline administration on the hearing function in BALB/c and DBA/2J mice, which strains exhibit moderate and rapid progressive high frequency hearing loss, respectively. The treatments were started at 1 month of age and lasted until almost a year and 5 months of age, respectively. In BALB/c mice, 4 mg/kg selegiline significantly mitigated the progression of ARHL at higher frequencies. Used in a wide dose range (0.15-45 mg/kg), selegiline had no effect in DBA/2J mice. Our results suggest that selegiline can partially preserve the hearing in certain forms of ARHL by alleviating its development. It might also be otoprotective in other mammals or humans.
Identifiants
pubmed: 33799684
pii: ijms22062853
doi: 10.3390/ijms22062853
pmc: PMC7999597
pii:
doi:
Substances chimiques
Antiparkinson Agents
0
Protective Agents
0
Selegiline
2K1V7GP655
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Hungarian Scientific Research Fund
ID : NKFI K128875
Organisme : Higher Education Institutional Excellence Programme of the Ministry of Human Capacities in Hungary, within the framework of the Neurology thematic programme of the Semmelweis University
ID : FIKP 2020
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