The Importance of Therapeutically Targeting the Binary Toxin from

ADP-Ribosylation / drug effects Actin Cytoskeleton / drug effects Actins / deficiency Anti-Bacterial Agents / therapeutic use Bacterial Proteins / antagonists & inhibitors Bacterial Toxins / antagonists & inhibitors Binding Sites Clostridioides difficile / drug effects Cross Infection / drug therapy Endocytosis / drug effects Enterocolitis, Pseudomembranous / drug therapy Enterotoxins / antagonists & inhibitors Epithelial Cells / drug effects Humans Models, Molecular Protein Binding Protein Domains Protein Interaction Domains and Motifs Protein Structure, Secondary
CDT CDTa CDTb Clostridioides difficile binary toxin infectious disease protein structural biology

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
13 Mar 2021
Historique:
received: 25 11 2020
revised: 03 03 2021
accepted: 09 03 2021
entrez: 3 4 2021
pubmed: 4 4 2021
medline: 24 4 2021
Statut: epublish

Résumé

Novel therapeutics are needed to treat pathologies associated with the

Identifiants

DOI: 10.3390/ijms22062926 PMID: 33805767 PMC: PMC8001090
pubmed: 33805767
pii: ijms22062926
doi: 10.3390/ijms22062926
pmc: PMC8001090
pii:
doi:

Substances chimiques

Actins 0
Anti-Bacterial Agents 0
Bacterial Proteins 0
Bacterial Toxins 0
Enterotoxins 0
tcdA protein, Clostridium difficile 0
toxB protein, Clostridium difficile 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R56 AI152397
Pays : United States

Références

New Microbes New Infect. 2014 Nov 08;3:12-7
pubmed: 25755885
PLoS Pathog. 2009 Oct;5(10):e1000626
pubmed: 19834554
Infect Immun. 1989 Jul;57(7):2107-14
pubmed: 2499545
Microb Pathog. 2008 Apr;44(4):265-70
pubmed: 18060735
Infect Immun. 2001 Oct;69(10):6004-11
pubmed: 11553537
Infect Immun. 1988 Sep;56(9):2299-306
pubmed: 3137166
J Biol Chem. 2015 May 29;290(22):14031-44
pubmed: 25882847
FEBS J. 2006 Oct;273(20):4579-93
pubmed: 16956368
Antimicrob Agents Chemother. 2015 Dec;59(12):7178-83
pubmed: 26149988
Toxins (Basel). 2016 May 03;8(5):
pubmed: 27153087
Vaccine. 2016 Mar 4;34(10):1319-23
pubmed: 26614590
Infect Immun. 2004 Jun;72(6):3267-75
pubmed: 15155629
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7399-404
pubmed: 18490658
J Biol Chem. 2009 Oct 16;284(42):28713-9
pubmed: 19692332
J Biol Chem. 2011 Aug 19;286(33):29356-29365
pubmed: 21705797
Microbiol Mol Biol Rev. 2004 Sep;68(3):373-402, table of contents
pubmed: 15353562
J Innate Immun. 2012;4(2):149-58
pubmed: 22237401
J Med Microbiol. 2005 Feb;54(Pt 2):181-185
pubmed: 15673514
Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1049-1058
pubmed: 31896582
FEMS Microbiol Rev. 2017 Nov 1;41(6):723-750
pubmed: 29048477
Biochem J. 2011 Jun 15;436(3):517-26
pubmed: 21615333
J Cell Biol. 1999 Aug 23;146(4):843-54
pubmed: 10459018
Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16756-61
pubmed: 15548616
FEMS Microbiol Rev. 2008 May;32(3):541-55
pubmed: 18397287
Annu Rev Microbiol. 2017 Sep 8;71:281-307
pubmed: 28657883
Biochem Biophys Res Commun. 1988 May 16;152(3):1361-8
pubmed: 2897847
mBio. 2013 Apr 30;4(3):e00244-13
pubmed: 23631918
Nat Struct Mol Biol. 2020 Mar;27(3):288-296
pubmed: 32123390
J Pharm Biomed Anal. 2020 Apr 15;182:113125
pubmed: 32004771
FEBS Lett. 2007 Apr 3;581(7):1287-96
pubmed: 17350628
Nat Rev Microbiol. 2014 Sep;12(9):599-611
pubmed: 25023120
Anaerobe. 2018 Oct;53:21-29
pubmed: 29524654
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16422-7
pubmed: 21930894
J Cell Commun Signal. 2012 Aug;6(3):125-38
pubmed: 22851429
Gut Microbes. 2014 Jan-Feb;5(1):15-27
pubmed: 24253566
Nature. 2015 May 28;521(7553):545-9
pubmed: 25778700
FEBS Lett. 2003 Nov 20;554(3):505-10
pubmed: 14623120
Biomol NMR Assign. 2016 Oct;10(2):335-9
pubmed: 27351891
J Proteome Res. 2005 Mar-Apr;4(2):523-31
pubmed: 15822930
Biochem J. 2004 Sep 15;382(Pt 3):769-81
pubmed: 15214846
Nat Microbiol. 2020 Jan;5(1):102-107
pubmed: 31712627
Eur J Biochem. 2004 Aug;271(15):3103-14
pubmed: 15265030
PLoS One. 2012;7(12):e51356
pubmed: 23236484
Infect Immun. 1997 Apr;65(4):1402-7
pubmed: 9119480
Biochem Biophys Res Commun. 2003 Jan 3;300(1):61-4
pubmed: 12480521
Nucleic Acids Res. 2017 Jan 4;45(D1):D200-D203
pubmed: 27899674
Biochim Biophys Acta. 2016 Mar;1858(3):512-25
pubmed: 26278641
N Engl J Med. 2005 Dec 8;353(23):2433-41
pubmed: 16322603
Biomol NMR Assign. 2016 Apr;10(1):213-7
pubmed: 26886352
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6139-6144
pubmed: 32123082
J Clin Microbiol. 2016 Jan;54(1):13-8
pubmed: 26511734
J Biol Chem. 2000 Jan 28;275(4):2328-34
pubmed: 10644682
FEBS Lett. 1996 Feb 19;380(3):291-5
pubmed: 8601443
Biochem Biophys Rep. 2016 Aug 11;8:55-61
pubmed: 28955942
Infect Immun. 2004 Apr;72(4):2186-93
pubmed: 15039342
Virulence. 2018;9(1):1085-1091
pubmed: 30052476
Toxins (Basel). 2018 Jan 18;10(1):
pubmed: 29346271
Toxins (Basel). 2018 Jun 01;10(6):
pubmed: 29865182
PLoS One. 2017 Jan 26;12(1):e0170640
pubmed: 28125650
Toxins (Basel). 2014 Sep 05;6(9):2626-56
pubmed: 25198129
Clin Vaccine Immunol. 2014 May;21(5):689-97
pubmed: 24623624

Auteurs

Dinendra L Abeyawardhane (DL)

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Raquel Godoy-Ruiz (R)

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Kaylin A Adipietro (KA)

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Kristen M Varney (KM)

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Richard R Rustandi (RR)

Merck & Co., Inc., Kenilworth, NJ 07033, USA.

Edwin Pozharski (E)

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
ORCID: 0000-0001-7012-5376

David J Weber (DJ)

Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Baltimore-Institute for Bioscience and Biotechnology Research, University of Maryland-Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA.
The Center for Biomolecular Therapeutics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
ORCID: 0000-0002-8824-1110

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › ADP-Ribosylation › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Cytosquelette d'actine › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Bactéries › Firmicutes › Clostridiales › Clostridioides › Clostridium difficile › The Importance of Therapeutically Targeting...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie iatrogène › Infection croisée › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Entérocolite › Entérocolite pseudomembraneuse › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Entérotoxines › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Cellules › Cellules épithéliales › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Éléments structuraux des protéines › Motifs et domaines d'intéraction protéique › The Importance of Therapeutically Targeting...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › The Importance of Therapeutically Targeting...