Analysis of the Structure and Biosynthesis of the Lipopolysaccharide Core Oligosaccharide of


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
23 Mar 2021
Historique:
received: 31 01 2021
revised: 17 03 2021
accepted: 18 03 2021
entrez: 3 4 2021
pubmed: 4 4 2021
medline: 11 5 2021
Statut: epublish

Résumé

Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, is important for bacterial viability in general and host-pathogen interactions in particular. Negative charges at its core oligosaccharide (core-OS) contribute to membrane integrity through bridging interactions with divalent cations. The molecular structure and synthesis of the core-OS have been resolved in various bacteria including the mammalian pathogen

Identifiants

pubmed: 33806795
pii: ijms22063250
doi: 10.3390/ijms22063250
pmc: PMC8005017
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Lipopolysaccharides 0
Oligosaccharides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : Emmy Noether programme RA2541/1

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Auteurs

Alexander Kutschera (A)

Chair of Phytopathology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising-Weihenstephan, Germany.

Ursula Schombel (U)

Division of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Parkallee 1-40, 23845 Borstel, Germany.

Dominik Schwudke (D)

Division of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Parkallee 1-40, 23845 Borstel, Germany.
German Center for Infection Research (DZIF), 23845 Borstel, Germany.
Airway Research Center North, Member of the German Center for Lung Research (DZL), 23845 Borstel, Germany.

Stefanie Ranf (S)

Chair of Phytopathology, TUM School of Life Sciences Weihenstephan, Technical University of Munich, 85354 Freising-Weihenstephan, Germany.

Nicolas Gisch (N)

Division of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz Lung Center, Parkallee 1-40, 23845 Borstel, Germany.

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Classifications MeSH