CD8+ T Cells in GCA and GPA: Bystanders or Active Contributors?
CD8+ T cells
aging
giant cell arteritis
granulomatosis with polyangiitis
vasculitis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
01
2021
accepted:
01
03
2021
entrez:
5
4
2021
pubmed:
6
4
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Vasculitis refers to inflammation of blood vessels and can cause a variety of serious complications depending on which vessels are affected. Two different forms of vasculitis are Giant Cell Arteritis (GCA) and Granulomatosis with Polyangiitis (GPA). GCA is the most common form of vasculitis in adults affecting the large arteries and can lead to visual impairment and development of aneurysms. GPA affects small- and medium-sized blood vessels predominantly in the lungs and kidneys resulting in organ failure. Both diseases can potentially be fatal. Although the pathogenesis of GCA and GPA are incompletely understood, a prominent role for CD4+ T cells has been implicated in both diseases. More recently, the role of CD8+ T cells has gained renewed interest. CD8+ T cells are important players in the adaptive immune response against intracellular microorganisms. After a general introduction on the different forms of vasculitis and their association with infections and CD8+ T cells, we review the current knowledge on CD8+ T-cell involvement in the immunopathogenesis of GCA and GPA focusing on phenotypic and functional features of circulating and lesional CD8+ T cells. Furthermore, we discuss to which extent aging is associated with CD8+ T-cell phenotype and function in GCA and GPA.
Identifiants
pubmed: 33815414
doi: 10.3389/fimmu.2021.654109
pmc: PMC8015776
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
654109Informations de copyright
Copyright © 2021 Reitsema, Boots, van der Geest, Sandovici, Heeringa and Brouwer.
Déclaration de conflit d'intérêts
AB was a consultant for Grünenthal Gmbh until 2017. EB as an employee of the UMCG received speaker/consulting fees from Roche paid to the UMCG. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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