The interaction of child abuse and rs1360780 of the FKBP5 gene is associated with amygdala resting-state functional connectivity in young adults.
FKBP5
amygdala
child abuse
gene-environment interaction
resting-state functional connectivity
rs1360780
salience network
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
05
03
2021
accepted:
25
03
2021
pubmed:
6
4
2021
medline:
8
3
2022
entrez:
5
4
2021
Statut:
ppublish
Résumé
Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p < .025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology.
Identifiants
pubmed: 33818852
doi: 10.1002/hbm.25433
pmc: PMC8193540
doi:
Substances chimiques
Tacrolimus Binding Proteins
EC 5.2.1.-
tacrolimus binding protein 5
EC 5.2.1.8
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3269-3281Subventions
Organisme : NIH HHS
ID : 5U54EB020403-05
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : European Research Council
ID : 695313
Pays : International
Organisme : MRF
ID : MRF_MRF-058-0004-RG-DESRI
Pays : United Kingdom
Organisme : NIH HHS
ID : MH085772-01A1
Pays : United States
Organisme : Medical Research Council
ID : MR/N000390/1
Pays : United Kingdom
Organisme : Science Foundation Ireland
ID : 16/ERCD/3797
Pays : Ireland
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : Medical Research Council
ID : MR/S020306/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States
Organisme : NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIH HHS
ID : R01DA049238
Pays : United States
Organisme : MRF
ID : MRF_MRF-058-0009-RG-DESR-C0759
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : R01 DA049238
Pays : United States
Organisme : Medical Research Council
ID : MR/R00465X/1
Pays : United Kingdom
Organisme : NIH HHS
ID : 1R56AG058854-01
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085772
Pays : United States
Informations de copyright
© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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