Limonene-carvacrol: A combination of monoterpenes with enhanced antileishmanial activity.
Animals
Antiprotozoal Agents
/ toxicity
Cell Survival
/ drug effects
Cymenes
/ toxicity
DNA-Directed DNA Polymerase
/ metabolism
Drug Combinations
Drug Synergism
Erythrocytes
/ drug effects
Hemolysis
/ drug effects
Immunologic Factors
/ toxicity
Leishmania major
/ drug effects
Limonene
/ toxicity
Lysosomes
/ drug effects
Macrophages
/ drug effects
Molecular Docking Simulation
NADH, NADPH Oxidoreductases
/ metabolism
Protozoan Proteins
/ metabolism
Sheep
Imunomodulation
Leishmania major
Molecular docking
Natural products
Journal
Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
20
11
2020
revised:
16
03
2021
accepted:
02
04
2021
pubmed:
7
4
2021
medline:
19
11
2021
entrez:
6
4
2021
Statut:
ppublish
Résumé
Leishmaniasis is a parasitosis with a wide incidence in developing countries. The drugs which are indicated for the treatment of this infection usually are able to promote high toxicity. A combination of limonene and carvacrol, monoterpenes present in plants with antiparasitic activity may constitute an alternative for the treatment of these diseases. In this study, the antileishmania activity against Leishmania major, cytotoxicity tests, assessment of synergism, parasite membrane damage tests as well as molecular docking and immunomodulatory activity of limonene-carvacrol (Lim-Car) combination were evaluated. The Lim-Car combination (5:0; 1:1; 1:4; 2:3; 3:2; 4:1 and 0:5) showed potential antileishmania activity, with mean inhibitory concentration (IC The 4:1 Lim-Car combination appears to be a promising candidate as a monotherapeutic antileishmania agent.
Sections du résumé
BACKGROUND
BACKGROUND
Leishmaniasis is a parasitosis with a wide incidence in developing countries. The drugs which are indicated for the treatment of this infection usually are able to promote high toxicity.
PURPOSE
OBJECTIVE
A combination of limonene and carvacrol, monoterpenes present in plants with antiparasitic activity may constitute an alternative for the treatment of these diseases.
METHODS
METHODS
In this study, the antileishmania activity against Leishmania major, cytotoxicity tests, assessment of synergism, parasite membrane damage tests as well as molecular docking and immunomodulatory activity of limonene-carvacrol (Lim-Car) combination were evaluated.
RESULTS
RESULTS
The Lim-Car combination (5:0; 1:1; 1:4; 2:3; 3:2; 4:1 and 0:5) showed potential antileishmania activity, with mean inhibitory concentration (IC
CONCLUSION
CONCLUSIONS
The 4:1 Lim-Car combination appears to be a promising candidate as a monotherapeutic antileishmania agent.
Identifiants
pubmed: 33823240
pii: S0887-2333(21)00083-7
doi: 10.1016/j.tiv.2021.105158
pii:
doi:
Substances chimiques
Antiprotozoal Agents
0
Cymenes
0
Drug Combinations
0
Immunologic Factors
0
Protozoan Proteins
0
carvacrol
9B1J4V995Q
Limonene
9MC3I34447
NADH, NADPH Oxidoreductases
EC 1.6.-
trypanothione reductase
EC 1.8.1.12
DNA-Directed DNA Polymerase
EC 2.7.7.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105158Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.