Ventromedial hypothalamic nucleus glycogen regulation of metabolic-sensory neuron AMPK and neurotransmitter expression: role of lactate.
AMP-Activated Protein Kinases
/ metabolism
Animals
Estradiol
/ pharmacology
Lactic Acid
/ metabolism
Neurotransmitter Agents
/ metabolism
Norepinephrine
/ pharmacology
Pituitary-Adrenal System
/ metabolism
Rats, Sprague-Dawley
Receptors, Estrogen
/ drug effects
Rhombencephalon
/ metabolism
Sensory Receptor Cells
/ metabolism
Ventromedial Hypothalamic Nucleus
/ metabolism
AMPK
glutamate decarboxylase
glycogen phosphorylase
l-lactate
nitric oxide synthase
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
pubmed:
8
4
2021
medline:
29
7
2021
entrez:
7
4
2021
Statut:
ppublish
Résumé
Astrocyte glycogen is dynamically remodeled during metabolic stability and provides oxidizable l-lactate equivalents during neuroglucopenia. Current research investigated the hypothesis that ventromedial hypothalamic nucleus (VMN) glycogen metabolism controls glucostimulatory nitric oxide (NO) and/or glucoinhibitory gamma-aminobutyric acid (GABA) neuron 5'-AMP-activated protein kinase (AMPK) and transmitter marker, e.g., neuronal nitric oxide synthase (nNOS), and glutamate decarboxylase
Identifiants
pubmed: 33825506
doi: 10.1152/ajpregu.00292.2020
pmc: PMC8285616
doi:
Substances chimiques
Neurotransmitter Agents
0
Receptors, Estrogen
0
Lactic Acid
33X04XA5AT
Estradiol
4TI98Z838E
AMP-Activated Protein Kinases
EC 2.7.11.31
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
R791-R799Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK109382
Pays : United States
Organisme : HHS | National Institutes of Health (NIH)
ID : DK 109382
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