Interleukin-1 and Systemic Sclerosis: Getting to the Heart of Cardiac Involvement.
Cytokines
/ metabolism
Disease Management
Disease Susceptibility
Energy Metabolism
Heart Diseases
/ etiology
Humans
Inflammasomes
/ metabolism
Inflammation
/ etiology
Inflammation Mediators
/ metabolism
Interleukin-1
/ antagonists & inhibitors
Molecular Targeted Therapy
Scleroderma, Systemic
/ complications
Signal Transduction
cellular metabolism
heart inflammation
inflammasome
interleukin-1
systemic sclerosis (scleroderma)
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
15
01
2021
accepted:
02
03
2021
entrez:
9
4
2021
pubmed:
10
4
2021
medline:
28
9
2021
Statut:
epublish
Résumé
Systemic sclerosis (SSc) is rare, severe connective tissue disease characterized by endothelial and vascular damage, immune activation, and resulting in inflammation and fibrosis of skin and internal organs, including the heart. SSc is associated with high morbidity and mortality. Cardiac involvement is frequent in SSc patients, even though often asymptomatic at early stages, and represents one of the major causes of SSc-related mortality. Heart involvement has a variable clinical presentation, and its pathogenesis is not completely understood. Myocardial fibrosis is traditionally considered the immunopathologic hallmark of heart involvement in SSc. This unique histological feature is paralleled by distinctive clinical and prognostic features. The so-called "vascular hypothesis" represents the most credited hypothesis to explain myocardial fibrosis. More recently, the prominent role of an inflammatory myocardial process has been identified as a cardinal event in the evolution to fibrosis, thus also delineating an "inflammation-driven pathway to fibrosis". The pro-inflammatory cytokine interleukin (IL)-1 has an apical and cardinal role in the myocardial inflammatory cascade and in cardiac dysfunction. The primary aim of this perspective article is: to present the emerging evidence on the role of IL-1 and inflammasome in both SSc and heart inflammation, to review the complex interplay between cellular metabolism and inflammasome activation, and to discuss the rationale for targeted inhibition of IL-1 for the treatment of SSc-heart involvement, providing preliminary experimental and clinical data to support this hypothesis.
Identifiants
pubmed: 33833766
doi: 10.3389/fimmu.2021.653950
pmc: PMC8021854
doi:
Substances chimiques
Cytokines
0
Inflammasomes
0
Inflammation Mediators
0
Interleukin-1
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
653950Informations de copyright
Copyright © 2021 De Luca, Cavalli, Campochiaro, Bruni, Tomelleri, Dagna and Matucci-Cerinic.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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