Synthesis, X-ray Structure Determination, and Comprehensive Photochemical Characterization of (Trifluoromethyl)diazirine-Containing TRPML1 Ligands.

Diazomethane Ligands Mass Spectrometry Photoaffinity Labels X-Rays

Journal

The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R

Informations de publication

Date de publication:
07 05 2021
Historique:
pubmed: 10 4 2021
medline: 6 7 2021
entrez: 9 4 2021
Statut: ppublish

Résumé

Potential (trifluoromethyl)diazirine-based TRPML1 ion channel ligands were designed and synthesized, and their structures were determined by single-crystal X-ray diffraction analysis. Photoactivation studies via

Identifiants

DOI: 10.1021/acs.joc.0c02993 PMID: 33835801
pubmed: 33835801
doi: 10.1021/acs.joc.0c02993
doi:

Substances chimiques

Ligands 0
Photoaffinity Labels 0
Diazomethane 60A625P70P

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6169-6183

Auteurs

Kevin Schwickert (K)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, 55128 Mainz, Germany.
ORCID: 0000-0002-2575-0380

Michał Andrzejewski (M)

Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.

Simon Grabowsky (S)

Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.
ORCID: 0000-0002-3377-9474

Tanja Schirmeister (T)

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Staudinger Weg 5, 55128 Mainz, Germany.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Composés azoïques › Composés diazonium › Diazo-méthane › Synthesis, X-ray Structure Determination, and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Synthesis, X-ray Structure Determination, and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Synthesis, X-ray Structure Determination, and...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Marqueurs d'affinité › Marqueurs de photoaffinité › Synthesis, X-ray Structure Determination, and...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Rayons X › Synthesis, X-ray Structure Determination, and...