In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord blood.
Cell Line, Tumor
Chlordecone
/ adverse effects
Cordocentesis
/ methods
DNA Methylation
/ genetics
Epigenesis, Genetic
/ genetics
Female
Fetal Blood
/ drug effects
Histone Code
/ drug effects
Histones
/ drug effects
Humans
Long Interspersed Nucleotide Elements
/ drug effects
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ metabolism
Promoter Regions, Genetic
/ genetics
Journal
Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
21
10
2020
revised:
26
03
2021
accepted:
29
03
2021
entrez:
10
4
2021
pubmed:
11
4
2021
medline:
13
10
2021
Statut:
epublish
Résumé
Environmental factors can induce detrimental consequences into adulthood life. In this study, we examined the epigenetic effects induced by in utero chlordecone (CD) exposure on human male cord blood as well as in blood-derived Ke-37 cell line. Genome-wide analysis of histone H3K4me3 distribution revealed that genes related to chromosome segregation, chromatin organization, and cell cycle have altered occupancy in their promoters. The affected regions were enriched in ESR1, SP family, and IKZF1 binding motifs. We also observed a global reduction in H3K9me3, markedly in repeated sequences of the genome. Decrease in H3K9me3 after CD exposure correlates with decreased methylation in LINE-1 promoters and telomere length extension. These observations on human cord blood were assessed in the Ke-37 human cell line. H3K4me3 and the expression of genes related to immune response, DNA repair, and chromatin organization, which were affected in human cord blood were also altered in CD-exposed Ke-37 cells. Our data suggest that developmental exposure to CD leads to profound changes in histone modification patterns and affects the processes controlled by them in human cord blood.
Identifiants
pubmed: 33837044
pii: 4/6/e202000944
doi: 10.26508/lsa.202000944
pmc: PMC8091598
pii:
doi:
Substances chimiques
Histones
0
histone H3 trimethyl Lys4
0
Chlordecone
RG5XJ88UDF
Banques de données
GENBANK
['U93565']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021 Legoff et al.
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