Measuring Cognitive Health in Ethnically Diverse Older Adults.
Aged
Cognition
Cognitive Aging
/ physiology
Cognitive Dysfunction
/ diagnosis
Cross-Cultural Comparison
Cultural Diversity
Educational Status
Ethnicity
/ education
Executive Function
Female
Healthy Aging
/ ethnology
Humans
Life Change Events
Male
Neuropsychological Tests
/ statistics & numerical data
United States
/ epidemiology
Cognition
Cross-cultural differences
Epidemiology
Neuropsychology
Journal
The journals of gerontology. Series B, Psychological sciences and social sciences
ISSN: 1758-5368
Titre abrégé: J Gerontol B Psychol Sci Soc Sci
Pays: United States
ID NLM: 9508483
Informations de publication
Date de publication:
03 02 2022
03 02 2022
Historique:
received:
01
09
2020
pubmed:
13
4
2021
medline:
3
3
2022
entrez:
12
4
2021
Statut:
ppublish
Résumé
Understanding racial/ethnic disparities in late-life cognitive health is a public health imperative. We used baseline data from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study to examine how age, education, gender, and clinical diagnosis, a proxy for brain health, are associated with cross-sectional measures of cognition in diverse racial/ethnic groups. Comprehensive measures of cognition were obtained using the Spanish and English Neuropsychological Assessment Scales and the National Institutes of Health Toolbox Cognitive Health Battery in a sample of 1,695 KHANDLE participants (Asians 24%, Blacks 26%, Latinos 20%, Whites 29%). A 25% random subsample was clinically evaluated and diagnosed with normal cognition, mild cognitive impairment (MCI), or dementia. Cognitive test scores were regressed on core demographic variables and diagnosis in the combined sample and in multiple group analyses stratified by racial/ethnic group. Race/ethnicity and education were variably associated with test scores with strongest associations with tests of vocabulary and semantic memory. Older age was associated with poorer performance on all measures, and gender differences varied across cognitive tests. Clinical diagnosis of MCI or dementia was associated with average decrements in test scores that ranged from -0.41 to -0.84 SD, with largest differences on tests of executive function and episodic memory. With few exceptions, associations of demographic variables and clinical diagnosis did not differ across racial/ethnic groups. The robust associations of cognitive test results with clinical diagnosis independent of core demographic variables and race/ethnicity support the validity of cognitive tests as indicators for brain health in diverse older adults.
Identifiants
pubmed: 33842969
pii: 6220426
doi: 10.1093/geronb/gbab062
pmc: PMC8824686
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
261-271Subventions
Organisme : NIA NIH HHS
ID : R01 AG052132
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG056519
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG052132
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG010129
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072972
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD041022
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
Neuropsychology. 2018 May;32(4):436-449
pubmed: 29494196
J Gerontol B Psychol Sci Soc Sci. 2019 Oct 4;74(8):1366-1375
pubmed: 30304527
Neuropsychology. 2005 Jul;19(4):466-75
pubmed: 16060821
Prog Neurobiol. 2014 Jun;117:20-40
pubmed: 24548606
Psychol Aging. 2009 Mar;24(1):116-28
pubmed: 19290743
J Gerontol B Psychol Sci Soc Sci. 2015 Jul;70(4):519-31
pubmed: 24389122
Ann Epidemiol. 2009 Nov;19(11):778-83
pubmed: 19656690
Alzheimer Dis Assoc Disord. 2019 Jul-Sep;33(3):179-185
pubmed: 31206372
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
J Gerontol B Psychol Sci Soc Sci. 2015 Jul;70(4):512-8
pubmed: 24184780
J Int Neuropsychol Soc. 2014 Jul;20(6):567-78
pubmed: 24959840
J Gerontol B Psychol Sci Soc Sci. 2002 Mar;57(2):P163-72
pubmed: 11867664
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
J Int Neuropsychol Soc. 2011 Jul;17(4):602-14
pubmed: 21092373
J Int Neuropsychol Soc. 2005 Sep;11(5):620-30
pubmed: 16212690
Neuropsychol Rev. 2008 Sep;18(3):223-54
pubmed: 18815889
Neurology. 1989 Sep;39(9):1159-65
pubmed: 2771064
Neuropsychology. 2016 Jul;30(5):517-24
pubmed: 27149552
Am J Epidemiol. 2009 Aug 1;170(3):331-42
pubmed: 19605514
Psychol Aging. 2010 Sep;25(3):606-19
pubmed: 20677882
Neuropsychology. 2014 Nov;28(6):846-58
pubmed: 24933483
Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):351-358
pubmed: 30376508
Neuropsychology. 2000 Apr;14(2):209-23
pubmed: 10791861
Psychol Aging. 2013 Sep;28(3):633-45
pubmed: 23437898
J Gerontol B Psychol Sci Soc Sci. 2015 Jul;70(4):557-67
pubmed: 24584038
Neurology. 2013 Mar 12;80(11 Suppl 3):S2-6
pubmed: 23479538
Neurology. 2013 Mar 12;80(11 Suppl 3):S54-64
pubmed: 23479546
J Int Neuropsychol Soc. 2008 Sep;14(5):746-59
pubmed: 18764970
Epidemiology. 2018 Jan;29(1):151-159
pubmed: 28863046
Am J Manag Care. 2007 Dec;13 Suppl 8:S193-7
pubmed: 18095782
J Int Neuropsychol Soc. 2002 Mar;8(3):341-8
pubmed: 11939693
Neuropsychology. 2011 Mar;25(2):260-269
pubmed: 21381830
Psychol Assess. 2004 Dec;16(4):347-59
pubmed: 15584794
SSM Popul Health. 2018 Sep 14;6:169-177
pubmed: 30310849
Psychol Aging. 2015 Dec;30(4):863-880
pubmed: 26523693
Int J Geriatr Psychiatry. 2016 Sep;31(9):1004-12
pubmed: 26766788
Alzheimers Dement. 2019 Jan;15(1):17-24
pubmed: 30243772