Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg.
Allosteric Regulation
Animals
Arachidonic Acids
/ metabolism
Brain Waves
/ drug effects
Cannabinoid Receptor Agonists
/ pharmacology
Cerebral Cortex
/ metabolism
Disease Models, Animal
Endocannabinoids
/ metabolism
Epilepsy, Absence
/ genetics
Female
Glycerides
/ metabolism
Indoles
/ pharmacology
Male
Rats
Receptor, Cannabinoid, CB1
/ drug effects
Animal model
Cannabinoid
Electroencephalogram
Epilepsy
Positive allosteric modulator
Type 1 cannabinoid receptor
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
30
01
2021
revised:
25
03
2021
accepted:
30
03
2021
pubmed:
13
4
2021
medline:
12
1
2022
entrez:
12
4
2021
Statut:
ppublish
Résumé
Childhood Absence Epilepsy (CAE) accounts for approximately 10% of all pediatric epilepsies. Current treatments for CAE are ineffective in approximately 1/3 of patients and can be associated with severe side effects such as hepatotoxicity. Certain cannabinoids, such as cannabidiol (CBD), have shown promise in the treatment of pediatric epilepsies. However, CBD remains limited or prohibited in many jurisdictions, and has not been shown to have efficacy in CAE. Modulation of the type 1 cannabinoid receptor (CB1R) may provide more desirable pharmacological treatments. Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model many aspects of CAE, including cortical spike and wave discharges (SWDs). We have recently demonstrated that Δ
Identifiants
pubmed: 33845076
pii: S0028-3908(21)00107-6
doi: 10.1016/j.neuropharm.2021.108553
pii:
doi:
Substances chimiques
3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole
0
Arachidonic Acids
0
Cannabinoid Receptor Agonists
0
Endocannabinoids
0
Glycerides
0
Indoles
0
Receptor, Cannabinoid, CB1
0
glyceryl 2-arachidonate
8D239QDW64
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108553Subventions
Organisme : CIHR
ID : 10677
Pays : Canada
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.