Survival implications of prescription opioid and benzodiazepine use in lung transplant recipients: Analysis of linked transplant registry and pharmacy fill records.
Adolescent
Adult
Analgesics, Opioid
/ pharmacology
Drug Prescriptions
/ statistics & numerical data
Female
Follow-Up Studies
Global Health
Humans
Incidence
Lung Transplantation
/ adverse effects
Male
Middle Aged
Opioid-Related Disorders
/ epidemiology
Pain, Postoperative
/ drug therapy
Registries
Retrospective Studies
Risk Factors
Survival Rate
/ trends
Transplant Recipients
Young Adult
benzodiazepines
lung transplant
mortality
opioids
pharmacy fills
Journal
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
ISSN: 1557-3117
Titre abrégé: J Heart Lung Transplant
Pays: United States
ID NLM: 9102703
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
21
07
2020
revised:
28
01
2021
accepted:
04
02
2021
pubmed:
14
4
2021
medline:
1
2
2022
entrez:
13
4
2021
Statut:
ppublish
Résumé
Prescription opioid and benzodiazepine use have been associated with morbidity and mortality among some groups of solid organ transplant recipients, but implications for outcomes among lung transplant patients are not well described. We conducted a retrospective cohort study using linked national transplant registry and pharmaceutical records to characterize the associations between benzodiazepine and opioid prescription fills in the years before and after lung transplant (2006-2017), with risk-adjusted posttransplant survival (adjusted hazard ratio, Among 11,568 recipients, 33.7% filled an opioid prescription, and 25.8% filled a benzodiazepine prescription before transplant. Compared to patients without prescriptions, those who filled both short- and long-acting benzodiazepine prescriptions before transplant had 2-fold higher mortality in the first year posttransplant (aHR, Benzodiazepine prescription fills before and after lung transplant, and opioid fills after transplant, are independently associated with posttransplant mortality. Review of benzodiazepine and opioid use history is relevant to risk-stratifying patients before and after lung transplant.
Sections du résumé
BACKGROUND
Prescription opioid and benzodiazepine use have been associated with morbidity and mortality among some groups of solid organ transplant recipients, but implications for outcomes among lung transplant patients are not well described.
METHODS
We conducted a retrospective cohort study using linked national transplant registry and pharmaceutical records to characterize the associations between benzodiazepine and opioid prescription fills in the years before and after lung transplant (2006-2017), with risk-adjusted posttransplant survival (adjusted hazard ratio,
RESULTS
Among 11,568 recipients, 33.7% filled an opioid prescription, and 25.8% filled a benzodiazepine prescription before transplant. Compared to patients without prescriptions, those who filled both short- and long-acting benzodiazepine prescriptions before transplant had 2-fold higher mortality in the first year posttransplant (aHR,
CONCLUSIONS
Benzodiazepine prescription fills before and after lung transplant, and opioid fills after transplant, are independently associated with posttransplant mortality. Review of benzodiazepine and opioid use history is relevant to risk-stratifying patients before and after lung transplant.
Identifiants
pubmed: 33846078
pii: S1053-2498(21)02177-X
doi: 10.1016/j.healun.2021.02.004
pmc: PMC8169588
mid: NIHMS1692791
pii:
doi:
Substances chimiques
Analgesics, Opioid
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
513-524Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK120518
Pays : United States
Informations de copyright
Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
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