Design, synthesis, and antiproliferative effect of 2,9-bis[4-(pyridinylalkylaminomethyl)phenyl]-1,10-phenanthroline derivatives on human leukemic cells by targeting G-quadruplex.
Antineoplastic Agents
/ chemical synthesis
Cell Line, Tumor
Drug Design
Fluorescence Resonance Energy Transfer
G-Quadruplexes
/ drug effects
HL-60 Cells
Humans
K562 Cells
Leukemia, Myeloid, Acute
/ drug therapy
Ligands
Phenanthrolines
/ chemical synthesis
Structure-Activity Relationship
Telomerase
/ metabolism
U937 Cells
1, 10-phenanthroline
FRET melting
G-quadruplex
G4 ligands
antiproliferative activity
leukemia
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
15
03
2021
received:
01
12
2020
accepted:
18
03
2021
pubmed:
15
4
2021
medline:
31
12
2021
entrez:
14
4
2021
Statut:
ppublish
Résumé
Current multiagent chemotherapy regimens have improved the cure rate in acute leukemia patients, but they are highly toxic and poorly efficient in relapsed patients. To improve the treatment approaches, new specific molecules are needed. The G-quadruplexes (G4s), which are noncanonical nucleic acid structures found in specific guanine-rich DNA or RNA, are involved in many cellular events, including control of gene expression. G4s are considered as targets for the development of anticancer agents. Heterocyclic molecules are well known to target and stabilize G4 structures. Thus, a new series of 2,9-bis[(substituted-aminomethyl)phenyl]-1,10-phenanthroline derivatives (1a-i) was designed, synthesized, and evaluated against five human myeloid leukemia cell lines (K562, KU812, MV4-11, HL60, and U937). Their ability to stabilize various oncogene promoter G4 structures (c-MYC, BCL-2, and K-RAS) as well as the telomeric G4 was also determined through the fluorescence resonance energy transfer melting assay and native mass spectrometry. In addition, the more bioactive ligands 1g-i were tested for telomerase activity in HuT78 and MV4-11 protein extracts.
Identifiants
pubmed: 33852185
doi: 10.1002/ardp.202000450
doi:
Substances chimiques
Antineoplastic Agents
0
Ligands
0
Phenanthrolines
0
Telomerase
EC 2.7.7.49
1,10-phenanthroline
W4X6ZO7939
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2000450Informations de copyright
© 2021 Deutsche Pharmazeutische Gesellschaft.
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