TIM-3 drives temporal differences in restimulation-induced cell death sensitivity in effector CD8
Antigens, CD
/ immunology
Apoptosis
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Cell Adhesion Molecules
/ immunology
Hepatitis A Virus Cellular Receptor 2
/ metabolism
Humans
Lymphocyte Activation
/ immunology
Membrane Proteins
/ metabolism
Signal Transduction
/ physiology
Transcription Factors
/ metabolism
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
14 04 2021
14 04 2021
Historique:
received:
28
12
2020
accepted:
25
03
2021
revised:
24
03
2021
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
18
9
2021
Statut:
epublish
Résumé
Immune homeostasis depends upon effective clearance of pathogens while simultaneously preventing autoimmunity and immunopathology in the host. Restimulation-induced cell death (RICD) is one such mechanism where by activated T cells receive subsequent antigenic stimulation, reach a critical signal threshold through the T cell receptor (TCR), and commit to apoptosis. Many details of this process remain unclear, including the role of co-stimulatory and co-inhibitory proteins that influence the TCR signaling cascade. Here we characterize the role of T cell immunoglobulin and mucin domain containing 3 (TIM-3) in RICD regulation. TIM-3 protected newly activated CD8
Identifiants
pubmed: 33854046
doi: 10.1038/s41419-021-03689-6
pii: 10.1038/s41419-021-03689-6
pmc: PMC8046753
doi:
Substances chimiques
Antigens, CD
0
CD66 antigens
0
Cell Adhesion Molecules
0
HAVCR2 protein, human
0
Hepatitis A Virus Cellular Receptor 2
0
Membrane Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
400Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM105821
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM139619
Pays : United States
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