Reference ranges for sphingosine-1-phosphate in neonates.
neonates
references ranges
sphingosine-1-phosphate
Journal
Journal of perinatal medicine
ISSN: 1619-3997
Titre abrégé: J Perinat Med
Pays: Germany
ID NLM: 0361031
Informations de publication
Date de publication:
27 Sep 2021
27 Sep 2021
Historique:
received:
21
11
2020
accepted:
31
03
2021
pubmed:
16
4
2021
medline:
27
1
2022
entrez:
15
4
2021
Statut:
epublish
Résumé
Sphingosine-1-phosphate (S1P) is a signalling lipid involved in embryonic development, physiological homeostasis, and pathogenic processes in multiple organ systems. Disturbance of S1P homeostasis has been associated with various human diseases in which the immune response and vascular integrity are severely compromised. Up-to-date, no study has analyzed S1P levels in neonates. The objective of this study was to determine S1P serum concentrations in neonates and establish S1P reference ranges. S1P levels in the umbilical cord blood of 460 term and preterm neonates were compared to a previously described cohort of healthy adult blood donors. S1P levels were further correlated with demographic characteristics, cellular sources of S1P, and inflammatory markers. The median S1P serum level in neonates was 1.70 μmol/L (IQR 1.41-1.97 μmol/L) and significantly higher than normal values reported in adults. S1P levels correlated positively with the number of red blood cells (p<0.001) and negatively with neutrophil precursors (p=0.028). Elevated S1P levels in neonates compared to adults possibly result from higher S1P content in its cellular sources due to the essential role of S1P during embryogenesis. Generated S1P ranges may be used as reference ranges for future studies in neonates.
Identifiants
pubmed: 33857362
pii: jpm-2020-0536
doi: 10.1515/jpm-2020-0536
doi:
Substances chimiques
Biomarkers
0
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
932-935Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
Références
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