Cancer Vaccines, Adjuvants, and Delivery Systems.
Adjuvants, Immunologic
/ administration & dosage
Animals
Antigens, Neoplasm
/ administration & dosage
Cancer Vaccines
/ administration & dosage
Drug Carriers
Drug Compounding
Drug Delivery Systems
Gene Transfer Techniques
Humans
Neoplasms
/ genetics
Tumor Escape
Tumor Microenvironment
Vaccines, DNA
/ administration & dosage
Vaccines, Synthetic
/ administration & dosage
mRNA Vaccines
DNA vaccine
adjuvant
cancer
peptide vaccine
vaccine
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
11
2020
accepted:
12
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
16
9
2021
Statut:
epublish
Résumé
Vaccination was first pioneered in the 18th century by Edward Jenner and eventually led to the development of the smallpox vaccine and subsequently the eradication of smallpox. The impact of vaccination to prevent infectious diseases has been outstanding with many infections being prevented and a significant decrease in mortality worldwide. Cancer vaccines aim to clear active disease instead of aiming to prevent disease, the only exception being the recently approved vaccine that prevents cancers caused by the Human Papillomavirus. The development of therapeutic cancer vaccines has been disappointing with many early cancer vaccines that showed promise in preclinical models often failing to translate into efficacy in the clinic. In this review we provide an overview of the current vaccine platforms, adjuvants and delivery systems that are currently being investigated or have been approved. With the advent of immune checkpoint inhibitors, we also review the potential of these to be used with cancer vaccines to improve efficacy and help to overcome the immune suppressive tumor microenvironment.
Identifiants
pubmed: 33859638
doi: 10.3389/fimmu.2021.627932
pmc: PMC8042385
doi:
Substances chimiques
Adjuvants, Immunologic
0
Antigens, Neoplasm
0
Cancer Vaccines
0
Drug Carriers
0
Vaccines, DNA
0
Vaccines, Synthetic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
627932Informations de copyright
Copyright © 2021 Paston, Brentville, Symonds and Durrant.
Déclaration de conflit d'intérêts
LD is CSO and shareholder in Scancell Ltd. SP, VB, and PS are employees of Scancell Ltd. The authors declare that this study was funded by Scancell Ltd. The funder was involved in the study design, collection, analysis, interpretation of data, the writing of this article and the decision to submit it for publication.
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