Maternal HLA Ib Polymorphisms in Pregnancy Allo-Immunization.
HLA class Ib
IgG4
anti-HLA alloimmunization
pregnancy
tolerance
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
01
2021
accepted:
15
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
30
9
2021
Statut:
epublish
Résumé
During pregnancy the formation of alloreactive anti-human leukocyte antigen (HLA) antibodies are a major cause of acute rejection in organ transplantation and of adverse effects in blood transfusion. The purpose of the study was to identify maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization in pregnancy and the degree of tolerance estimated by IgG4 expression. In total, 86 primiparous women with singleton pregnancies were included in the study. Maternal blood samples and umbilical cord samples were collected at delivery. Clinical data were obtained. Maternal blood serum was screened for HLA class I and II antibodies, identification of Donor Specific Antibody (DSA), activation of complement measured by C1q and IgG4 concentrations. Mothers were genotyped for HLA class Ib (
Identifiants
pubmed: 33859649
doi: 10.3389/fimmu.2021.657217
pmc: PMC8042285
doi:
Substances chimiques
HLA-DQ Antigens
0
Immunoglobulin G
0
Isoantibodies
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
657217Informations de copyright
Copyright © 2021 Persson, Picard, Marin, Isgaard, Stæhr, Molinari, Chiaroni, Lebech, Hviid and Di Cristofaro.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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