The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Adult
Aged, 80 and over
Alleles
Animals
Arthritis, Rheumatoid
/ blood
Autoantigens
/ immunology
Citrullination
/ immunology
Epitopes, T-Lymphocyte
/ genetics
Female
HLA-DR4 Antigen
/ genetics
HLA-DRB1 Chains
/ genetics
Humans
Male
Mice, Transgenic
Receptors, Antigen, T-Cell
/ metabolism
T-Lymphocytes
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
16 04 2021
16 04 2021
Historique:
received:
30
07
2020
accepted:
18
03
2021
entrez:
17
4
2021
pubmed:
18
4
2021
medline:
1
3
2022
Statut:
ppublish
Résumé
Individuals expressing HLA-DR4 bearing the shared susceptibility epitope (SE) have an increased risk of developing rheumatoid arthritis (RA). Posttranslational modification of self-proteins via citrullination leads to the formation of neoantigens that can be presented by HLA-DR4 SE allomorphs. However, in T cell-mediated autoimmunity, the interplay between the HLA molecule, posttranslationally modified epitope(s), and the responding T cell repertoire remains unclear. In HLA-DR4 transgenic mice, we show that immunization with a Fibβ-74cit
Identifiants
pubmed: 33863750
pii: 6/58/eabe0896
doi: 10.1126/sciimmunol.abe0896
pii:
doi:
Substances chimiques
Autoantigens
0
Epitopes, T-Lymphocyte
0
HLA-DR4 Antigen
0
HLA-DRB1 Chains
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.